Ordering Recommendation

Use to optimize dosing and monitor patient adherence.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Timing of specimen collection: Predose (trough) draw at steady-state concentration.


Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).


After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months


Quantitative Liquid Chromatography-Tandem Mass Spectrometry


Mon, Wed, Fri


1-7 days

Reference Interval

Effective February 19, 2013

Therapeutic Range Total (clomipramine and norclomipramine): 220-500 ng/mL
Toxic Level Greater than 900 ng/mL

Interpretive Data

The therapeutic range listed relates to the antidepressant characteristics of the drug. A therapeutic range for treating obsessive compulsive disorder is not well established. Toxic concentrations may cause anticholinergic effects, CNS depression, cardiac abnormalities, seizures, and hypotension.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes

80335 (Alt code: G0480)


Component Test Code* Component Chart Name LOINC
0099320 Clomipramine/Norclomipramine, Total, SP 3493-4
0099335 Norclomipramine, SP 3536-0
0099437 Clomipramine (Anafranil), SP 3491-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Anafranil
  • Desmethylclomipramine
  • Norclomipramine
Clomipramine and Metabolite, Serum or Plasma (Test on Referral as of 03/05/24)