Optimize drug therapy and monitor patient adherence.
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Mon, Wed, Fri
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months
Effective February 19, 2013
|Therapeutic Range||Total (clomipramine and norclomipramine): 220-500 ng/mL|
|Toxic Level||Greater than 900 ng/mL|
The therapeutic range listed relates to the antidepressant characteristics of the drug. A therapeutic range for treating obsessive compulsive disorder is not well established. Toxic concentrations may cause anticholinergic effects, CNS depression, cardiac abnormalities, seizures and hypotension.
Laboratory Developed Test (LDT)
80335 (Alt code: G0480)
|Component Test Code*||Component Chart Name||LOINC|
|0099320||Clomipramine/Norclomipramine, Total, SP||3493-4|
|0099437||Clomipramine (Anafranil), SP||3491-8|