ReportedExpected turnaround time for a result, beginning when ARUP has received the specimen.
1-4 days
New York DOH Approval StatusIndicates test has been approved by the New York State Department of Health.
This test is New York DOH approved.
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Collect
Plain red.
Specimen Preparation
Separate serum from cells within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Light blue (citrate), gray (oxalate), green (heparin), K2EDTA plasma, tubes that contain liquid anticoagulant, or gel separator tubes.
Remarks
Stability
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month
Reference IntervalNormal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Test Number
Components
Therapeutic Range
0099308
Valproic Acid, Total
Therapeutic Range: 50-125 µg/mL Toxic: Greater than 150 µg/mL
0099791
Valproic Acid, Free
Effective November 18, 2013 Therapeutic Range: 7-23 µg/mL Toxic: Greater than 30 µg/mL
0099309
Valproic Acid, Percent Free
5-18 percent
Interpretive DataBackground information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.
Free valproic acid may be important to monitor in patients with altered or unpredictable protein binding capacity because valproic acid exhibits variable, dose-dependent protein binding. Valproic acid is also subject to drug-drug interactions due to displacement of protein binding. Calculating percent free attempts to minimize differences in test cross-reactivity and may be useful in dose optimization. Adverse effects may include headache, somnolence and dizziness.
Compliance Category
FDA
NoteAdditional information related to the test.
Hotline History
N/A
CPT CodesThe American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
AliasesOther names that describe the test. Synonyms.