Ordering Recommendation
May be useful to detect central nervous system systemic lupus erythematosus (SLE), which is somewhat rare, or renal involvement in SLE.
Mnemonic
Methodology
Semi-Quantitative Multiplex Bead Assay
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)
Refrigerated.
Plasma or other body fluids. Bacterially contaminated or severely lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
29 AU/mL or less | Negative |
30-40 AU/mL | Equivocal |
41 AU/mL or greater | Positive |
Interpretive Data
Autoantibodies reacting with cytoplasmic ribosomes are highly specific for systemic lupus erythematosus. Ribosomal-P antibodies are found in approximately 12% of patients with systemic lupus erythematosus (SLE) and in 90% of patients with lupus psychosis; titers often increase more than fivefold during and before active phases of psychosis.
FDA
Note
Hotline History
Hotline History
CPT Codes
83516
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0099249 | Ribosome P Antibody, IgG | 13636-6 |
Aliases
- Anti-Ribosome P Antibodies
- Ribosomal P Antibodies
- Ribosome Antibody
- rRNP