Ordering Recommendation

Measure total tryptase to confirm mast cell activation in diseases such as mastocytosis, anaphylaxis, urticaria, and asthma. Not generally used acutely except where diagnosis is unclear. Useful in prognosis of systemic mastocytosis.

Mnemonic
TRYPT
Methodology

Quantitative Fluorescent Enzyme Immunoassay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Allow serum to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions
Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 72 hours; Frozen: 1 month

Reference Interval

Less than 11.0 µg/L

Interpretive Data



Compliance Category

FDA

Note

This test measures total tryptase and does not distinguish between the alpha and beta protein types. Samples should preferably be collected between 15 minutes and three hours after the event suspected to have caused mast cell activation.

Hotline History
N/A
CPT Codes

83520

Components
Component Test Code* Component Chart Name LOINC
0099173 Tryptase 21582-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Total Tryptase
  • Tryptase, Autopsy (Tryptase)
Tryptase