Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic

OXCARB

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2 EDTA).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Remarks
Stability

After separation from cells: Ambient: 6 weeks; Refrigerated: 6 weeks; Frozen: 3 months (avoid repeated freeze/thaw cycles)

Reference Interval

Effective November 18, 2013

Therapeutic Range: 3-35 µg/mL
Toxic: Greater than 40 µg/mL

Interpretive Data

This test measures monohydroxyoxcarbazepine (MHD). Adverse effects may include dizziness, fatigue, nausea, headache, somnolence, ataxia and tremor.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

80183

Components

Component Test Code* Component Chart Name LOINC
0098834 Oxcarb or Eslicarb Metabolite (MHD) 31019-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 10-Hydroxy-10,11-Dihydrocarbamazepine
  • 10-Hydroxycarbazepine
  • 10-OH-Carbazepine (MHD)
  • 11-Dihydrocarbamazepine
  • Eslicarbazepine
  • GP 47680
  • Metabolite of Oxcarbazepine
  • MHC
  • MHD
  • Monohydroxy Carbamazepine
  • Monohydroxy Carbamazepine (MHD)
  • Oxcarbazepine
  • Oxcarbazepine Metabolite
  • Oxcarbazepine Metabolite, 10-Hydroxy-10
  • Trileptal (Parent Pro-Drug)
Oxcarbazepine or Eslicarbazepine Metabolite (MHD)