Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
OXCARB
Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2 EDTA).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Remarks
Stability

After separation from cells: Ambient: 6 weeks; Refrigerated: 6 weeks; Frozen: 3 months (avoid repeated freeze/thaw cycles)

Reference Interval

Effective November 18, 2013

Therapeutic Range: 3-35 µg/mL
Toxic: Greater than 40 µg/mL

Interpretive Data

This test measures monohydroxyoxcarbazepine (MHD). Adverse effects may include dizziness, fatigue, nausea, headache, somnolence, ataxia and tremor. 

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

80183

Components
Component Test Code* Component Chart Name LOINC
0098834 Oxcarb or Eslicarb Metabolite (MHD) 31019-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 10-Hydroxy-10,11-Dihydrocarbamazepine
  • 10-Hydroxycarbazepine
  • 10-OH-Carbazepine (MHD)
  • 11-Dihydrocarbamazepine
  • Eslicarbazepine
  • GP 47680
  • Metabolite of Oxcarbazepine
  • MHC
  • MHD
  • Monohydroxy Carbamazepine
  • Monohydroxy Carbamazepine (MHD)
  • Oxcarbazepine
  • Oxcarbazepine Metabolite
  • Oxcarbazepine Metabolite, 10-Hydroxy-10
  • Trileptal (Parent Pro-Drug)
Oxcarbazepine or Eslicarbazepine Metabolite (MHD)