Ordering Recommendation

Optimize drug therapy and monitor patient adherence.


Quantitative Liquid Chromatography-Tandem Mass Spectrometry


Tue, Fri


1-7 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.


Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transport 2 mL serum or plasma. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution). Hemolyzed samples.


Olanzapine shows slight interference with high levels of hemolysis in the sample. Noroxycodone causes an analytical interference and impacts the quantitation of Olanzapine.


After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month

Reference Interval

Effective November 15, 2021

Therapeutic Range: 20-80 ng/mL
Toxic: Greater than or equal to 100 ng/mL

Interpretive Data

Olanzapine is an antipsychotic drug indicated for the treatment of depression and bipolar disorder. The therapeutic range is based on serum, predose (trough) draw collection at steady-state concentration. Adverse effects may include dizziness, fatigue, akathisia, postural hypotension, delirium, somnolence, neuroleptic malignant syndrome, hyperglycemia and muscle weakness agitation.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes

80342 (Alt code: G0480)


Component Test Code* Component Chart Name LOINC
0098833 Olanzapine 12389-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


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