Ordering Recommendation

May be useful in the assessment of chromium deficiency or overload. For the assessment of hexavalent chromium exposure, Chromium, RBC (2014505) is preferred.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).


Royal Blue (No Additive).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL)

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated or frozen.

Unacceptable Conditions

Plasma. Royal Blue (EDTA) or separator tubes. Specimens that are not separated from the clot within 2 hours. Specimens transported in tubes other than specified.


Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely


Quantitative Inductively Coupled Plasma-Mass Spectrometry




1-4 days

Reference Interval

Less than or equal to 5.0 µg/L

Interpretive Data

Elevated results may be due to skin or collection-related contamination, including the use of a noncertified metal-free collection/transport tube. If contamination concerns exist due to elevated levels of serum chromium, confirmation with a second specimen collected in a certified metal-free tube is recommended.

Serum chromium levels can be significantly higher in patients with metal-on-metal total hip replacement implants than in control patients without metal implants. Serum chromium levels may be increased in asymptomatic patients with metal-on-metal prosthetics and should be considered in the context of the overall clinical scenario. Whole blood is the specimen type recommended by the U.S. Food and Drug Administration for assessing the risks of metal-on-metal hip implants in symptomatic patients.

Symptoms associated with chromium toxicity vary based on route of exposure and dose, and may include dermatitis, impairment of pulmonary function, gastroenteritis, hepatic necrosis, bleeding, and acute tubular necrosis. 

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0098830 Chromium, Serum 5622-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Cr, Blood
  • CRS
  • serum chromium levels
  • serum metal ion concentration
Chromium, Serum