Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
KEPPRA
Methodology

Quantitative Enzyme Immunoassay

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect

Plain red. Also acceptable: Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).

Specimen Preparation

Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Serum or plasma separator tubes. Grossly hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: 7 days; Refrigerated: 1 week; Frozen: 1 month

Reference Interval

Effective November 18, 2013

Therapeutic range: 12-46 µg/mL
Toxic:              Not well established

Interpretive Data

Pharmacokinetics of levetiracetam are affected by renal function. Adverse effects may include somnolence, weakness, headache and vomiting.

This levetiracetam (Keppra) immunoassay uses the ARK Diagnostics reagents, which has known cross-reactivity with the drug brivaracetam (Briviact) and may report inaccurate results. Patients transitioning from levetiracetam to brivaracetam or those who are using both medications should not monitor drug concentrations with the ARK Diagnostics assay. These patients should be monitored using a validated chromatographic methodology that distinguishes between drugs to determine drug concentrations.

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

80177

Components
Component Test Code* Component Chart Name LOINC
0098627 Keppra (Levetiracetam) 30471-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • anti-epileptic
  • Keppra
  • keppra blood concentration
  • Keppra concentration
  • Keppra level, Keppra blood level
  • Levetiracetam
Keppra (Levetiracetam)