Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
ITRACONAZ
Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Tue, Thu, Sat

Reported

1-6 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect

Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Serum separator tubes. Hemolyzed or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months

Reference Interval

Effective August 15, 2011

Therapeutic Ranges
Itraconazole (trough) - Localized Infection Greater than 0.5 µg/mL
Itraconazole (trough) - Systemic Infection Greater than 1.0 µg/mL
Hydroxyitraconazole No therapeutic range established

Interpretive Data

Itraconazole and hydroxyitraconazole concentrations combined should not exceed 10 µg/mL. Adverse effects may include nausea, vomiting and rash.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
CPT Codes

80299

Components
Component Test Code* Component Chart Name LOINC
0098517 Itraconazole, Quantitative by LC-MS/MS 10989-2
0098518 Hydroxyitraconazole, Quantitative 18337-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Antifungal Serum Level
  • itranconazole blood level
  • Sporanox
  • sporanox blood concentration
  • Sporanox blood level
Itraconazole, Quantitative by LC-MS/MS