Optimize drug therapy and monitor patient adherence.
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Tue, Thu, Sat
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL)
Serum separator tubes. Hemolyzed or lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months
Effective August 15, 2011
|Itraconazole (trough) - Localized Infection||Greater than 0.5 µg/mL|
|Itraconazole (trough) - Systemic Infection||Greater than 1.0 µg/mL|
|Hydroxyitraconazole||No therapeutic range established|
Itraconazole and hydroxyitraconazole concentrations combined should not exceed 10 µg/mL. Adverse effects may include nausea, vomiting and rash.
Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
|Component Test Code*||Component Chart Name||LOINC|
|0098517||Itraconazole, Quantitative by LC-MS/MS||10989-2|
- Antifungal Serum Level
- itranconazole blood level
- sporanox blood concentration
- Sporanox blood level