Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
ITRACONAZ
Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Tue, Thu, Sat

Reported

1-6 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect

Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Serum separator tubes. Hemolyzed or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months

Reference Interval

Effective August 15, 2011

Therapeutic Ranges
Itraconazole (trough) - Localized Infection Greater than 0.5 µg/mL
Itraconazole (trough) - Systemic Infection Greater than 1.0 µg/mL
Hydroxyitraconazole No therapeutic range established

Interpretive Data

Itraconazole and hydroxyitraconazole concentrations combined should not exceed 10 µg/mL. Adverse effects may include nausea, vomiting and rash.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

80299

Components
Component Test Code* Component Chart Name LOINC
0098517 Itraconazole, Quantitative by LC-MS/MS 10989-2
0098518 Hydroxyitraconazole, Quantitative 18337-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Antifungal Serum Level
  • itranconazole blood level
  • Sporanox
  • sporanox blood concentration
  • Sporanox blood level
Itraconazole, Quantitative by LC-MS/MS