Optimize drug therapy and monitor patient adherence.
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Within 24 hours
Pre-dose (trough) levels should be drawn.
Lavender (EDTA) or pink (K2EDTA).
Transport 1 mL whole blood. (Min: 0.25 mL)
Serum or plasma. Specimens left at room temperature for longer than 24 hours. Clotted specimens.
Ambient: 24 hours; Refrigerated: 1 week; Frozen: 2 months
Effective February 18, 2014
|Kidney transplant (in combination with Cyclosporine):||4-12 ng/mL|
|Toxic value:||Greater than 25 ng/mL|
A range of 12-20 ng/mL has been suggested for liver transplant. The optimal therapeutic range for a given patient may differ from this suggested range based on the indication for therapy, treatment phase (initiation or maintenance), use in combination with other drugs, time of specimen collection relative to prior dose, type of transplanted organ, and/or the therapeutic approach of the transplant center.
Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
Sirolimus (Rapamune) whole blood concentrations can be measured by either chromatographic or immunoassay methodologies. These two methodologies are not directly interchangeable and the measured sirolimus whole blood concentration depends on the methodology used. Reference ranges may vary according to the specific immunoassay or HPLC-MS/MS test. Generally, immunoassays have been reported to have a positive bias relative to HPLC-MS/MS assays due to the detection of antibody cross-reactivity with sirolimus metabolites.
|Component Test Code*||Component Chart Name||LOINC|
|0098467||Sirolimus by HPLC-MS/MS||29247-4|