Ordering Recommendation
Optimize drug therapy and monitor patient adherence.
Mnemonic
Methodology
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Tue, Thu, Sat
Reported
1-6 days
New York DOH Approval Status
Specimen Required
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.6 mL)
Frozen.
Whole blood. Gel separator tubes, Light Blue (citrate), or Yellow (SPS or ACD solution).
After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months
Reference Interval
Effective August 15, 2011
Therapeutic Range: 5.0-20.0 µg/mL
Interpretive Data
Fluconazole is a synthetic triazole antifungal drug indicated to treat candidiasis and cryptococcal meningitis infections. The therapeutic range is based on serum, predose (trough) draw collection at steady-state concentration. The pharmacokinetics of fluconazole are influenced by drug-drug interactions when coadministered with drugs metabolized by cytochrome P450 2C9, 2C19 and 3A4 enzymes. Adverse effects may include headache, skin rash, abdominal pain and hepatitis.
Laboratory Developed Test (LDT)
Note
Hotline History
Hotline History
CPT Codes
80299
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0097621 | Fluconazole, Quantitative by LC-MS/MS | 10987-6 |
Aliases
- Diflucan