Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.


Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.6 mL)

Storage/Transport Temperature


Unacceptable Conditions

Whole blood. Gel separator tubes, Light Blue (citrate), or Yellow (SPS or ACD solution).


After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months


Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry


Tue, Thu, Sat


1-6 days

Reference Interval

Effective August 15, 2011

Therapeutic Range: 5.0-20.0 µg/mL

Interpretive Data

Fluconazole is a synthetic triazole antifungal drug indicated to treat candidiasis and cryptococcal meningitis infections. The therapeutic range is based on serum, predose (trough) draw collection at steady-state concentration. The pharmacokinetics of fluconazole are influenced by drug-drug interactions when coadministered with drugs metabolized by cytochrome P450 2C9, 2C19 and 3A4 enzymes. Adverse effects may include headache, skin rash, abdominal pain and hepatitis.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0097621 Fluconazole, Quantitative by LC-MS/MS 10987-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Diflucan
Fluconazole, Quantitative by LC-MS/MS