Optimize drug therapy and monitor patient adherence.
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Tue, Thu, Sat
New York DOH Approval Status
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Plain Red, Lavender (EDTA), or Green (Sodium or Lithium Heparin).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.6 mL)
Whole blood. Gel separator tubes, Light Blue (citrate), or Yellow (SPS or ACD solution).
After separation from cells: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: 6 months
Effective August 15, 2011
Therapeutic Range: 5.0-20.0 µg/mL
Fluconazole is a synthetic triazole antifungal drug indicated to treat candidiasis and cryptococcal meningitis infections. The therapeutic range is based on serum, predose (trough) draw collection at steady-state concentration. The pharmacokinetics of fluconazole are influenced by drug-drug interactions when coadministered with drugs metabolized by cytochrome P450 2C9, 2C19 and 3A4 enzymes. Adverse effects may include headache, skin rash, abdominal pain and hepatitis.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0097621||Fluconazole, Quantitative by LC-MS/MS||10987-6|