Lymphocyte Antigen and Mitogen Proliferation Panel

0096056
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Example Reports
Abnormal
Normal

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Time Sensitive

Ordering Recommendation

Evaluate patients with suspected immunodeficiency diseases, including severe combined immunodeficiency. Do not order for patients younger than 3 months unless clinical history of candidiasis is present.

Mnemonic

LAM

Methodology

Cell Culture

Performed

Sun, Tue, Wed, Thu, Fri, Sat

Reported

9-10 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Collect control specimen from a healthy individual unrelated to patient at approximately the same time as and under similar conditions to the patient.

Collect

Green (sodium heparin) (patient) AND green (sodium heparin) (control). Also acceptable: Yellow (ACD Solution A) (patient) AND yellow (ACD Solution A) (control). Patient and control specimens must be collected within 48 hours of test performance.

Specimen Preparation

Transport 10 mL whole blood (patient) AND 10 mL whole blood (control) in original collection tubes. (Min: 7 mL (patient) AND 7 mL (control)) Do not refrigerate or freeze. LIVE LYMPHOCYTES REQUIRED.
Infant Minimum: 3 mL (patient) AND 7 mL (control).

Storage/Transport Temperature

CRITICAL ROOM TEMPERATURE.

Unacceptable Conditions

Yellow (ACD Solution B). Refrigerated or frozen specimens. Specimens in transport longer than 48 hours.

Remarks
Stability

Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable
New York State Clients: Ambient 24 hours; Refrigerated: Unacceptable; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Phytohemagglutinin, concanavalin A, pokeweed mitogen, Candida antigen, and tetanus antigen are tested independently in lymphocyte culture. Lymphocyte proliferation in response to these mitogens and antigens is determined by 3H-thymidine incorporation.

Results are reported as the counts per minute (CPM) mitogen or antigen stimulated versus a control culture and a stimulation index (SI) which represents the ratio of CPM of the stimulated lymphocytes to the mean CPM of the unstimulated control.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Interpretation comparing the patient results to the client normal control and the laboratory control will be provided by the medical director.

Hotline History

N/A

CPT Codes

86353 x5

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Components

Component Test Code* Component Chart Name LOINC
0096056 Lymphocyte Ag and Mitogen Panel 59063-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Antigen & Mitogen Proliferation Panel
  • Blastogenesis Antigens
  • Blastogenesis Mitogens
  • Lymphocyte Blastogenesis
  • Lymphocyte Blastogenesis Antigens
  • Mitogen Studies
Lymphocyte Antigen and Mitogen Proliferation Panel