Ordering Recommendation

Aid in detecting past dengue infection. Testing should also be considered for other arthropod-borne viruses with similar symptomology based on clinical presentation and travel history.

Mnemonic
DEN G
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Mon, Wed, Fri

Reported

1-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as "acute or convalescent."

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

1.64 IV or less: Negative - No significant level of detectable dengue fever virus IgG antibody.
1.65-2.84 IV: Equivocal - Questionable presence of antibodies.  Repeat testing in 10-14 days may be helpful.
2.85 IV or greater: Positive - IgG antibody to dengue fever virus detected, which may indicate a current or past infection.

Interpretive Data

Patients in the early stage of dengue fever virus infection may not have detectable IgG antibodies, as the IgG response may take several weeks to develop.  In the absence of detectable IgG, testing for IgM class antibody is strongly recommended.  The best evidence for current infection is a significant change on two appropriately timed specimens, where both tests are done in the same laboratory at the same time.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

86790

Components
Component Test Code* Component Chart Name LOINC
0093097 Dengue Fever Virus Antibody, IgG 23991-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Dengue Fever IgG
  • Dengue Fever Virus IgG antibody
  • Flavivirus
Dengue Fever Virus Antibody, IgG