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Bile Acids, Fractionated and Total by LC-MS/MS
Ordering Recommendation
Aids in the evaluation of liver function and intrahepatic cholestasis of pregnancy. Use to monitor patients on bile acid therapy. This assay is not useful for the diagnosis of inborn errors of bile acid metabolism.
New York DOH Approval Status
Specimen Required
Fasting for a minimum of eight hours prior to specimen collection is recommended.
Plain red or serum separator tube.
After clot formation, centrifuge specimen and pour off serum into a transport tube. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.2 mL)
Refrigerated. Store specimen refrigerated or frozen.
Ambient: 8 hours; Refrigerated: 2 weeks; Frozen: 3 months
Methodology
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Tue, Thu, Sat
Reported
1-6 days
Reference Interval
7 years and older:
Cholic acid (CA) 0-1.9 µmol/L
Chenodeoxycholic acid (CDC) 0-3.4 µmol/L
Deoxycholic acid (DCA) 0-2.5 µmol/L
Ursodeoxycholic acid (UDC) 0-1.0 µmol/L
Total 0-7.0 µmol/L
Interpretive Data
The reference intervals were established in fasting individuals. Mild elevation of bile acids could be secondary to nonfasting. For a more accurate interpretation of the results, a fasting specimen is recommended for this test.
Laboratory Developed Test (LDT)
Note
Reference intervals were derived using samples obtained after an overnight fast.
Hotline History
CPT Codes
83789
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0092611 | Total Cholic Acid | 30518-5 |
| 0092612 | Total Deoxycholic Acid | 30520-1 |
| 0092613 | Total Chenodeoxycholic Acid | 30519-3 |
| 0092614 | Total Bile Acids | 14628-2 |
| 0093240 | Total Ursodeoxycholic Acid | 55159-8 |
Aliases
- Chenodeoxycholic Acid
- Cholic Acid
- Deoxycholic Acid
- Fractionated Bile Acids
- Ursodeoxycholic Acid (UDC)
- Bile Salts
