Natural Killer Cells Enumeration
Ordering Recommendation
Evaluate NK cells in patients with suspected immune deficiency.
New York DOH Approval Status
Specimen Required
Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin). Hemogard tubes are preferred for laboratory automation and safety.
Transport 4 mL whole blood. (Min: 0.5 mL)
CRITICAL ROOM TEMPERATURE.
Clotted or hemolyzed specimens.
Specimens must be analyzed within stability times provided. Some medication may affect immunophenotyping results and should be provided on the patient test request form.
EDTA: Ambient: 72 hours; Refrigerated: Unacceptable; Frozen: Unacceptable
Heparin: Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable
New York State Clients: Same as the above.
Methodology
Quantitative Flow Cytometry
Performed
Sun-Sat
Reported
1-3 days
Reference Interval
Effective November 16, 2015
Reference Interval Notes:
Pediatric reference values (0 - 6 days up to 10 - 15 years) taken from Scandinavian Journal of Immunology 2012; 75, 436-444.
Adult and Geriatric (16 - 64 and 65 plus years) ranges were developed in-lab.
Test Number |
Components |
Reference Interval |
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% Natural Killer Cells |
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Absolute Natural Killer Cells |
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Interpretive Data
The results reported are the percentage of lymphocytes that are Natural killer (NK) cells and the absolute count of NK-cells per µL of blood. Only those cells that express CD45 and either CD16 or CD56 (or both) but not CD3 or CD19 are reported.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
86357
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0092403 | Natural Killer Cell Information | 77202-0 |
0095701 | % Natural Killer Cells | 32519-1 |
0095702 | Absolute Natural Killer Cells | 20604-5 |
Aliases
- Natural Killer Cell CD56/CD16, Percent and Absolute
- NK absolute cell count and percentage