Ordering Recommendation
Monitor patient adherence.
Mnemonic
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Mon, Wed, Fri
Reported
1-4 days
New York DOH Approval Status
Specimen Required
Gray (sodium fluoride/potassium oxalate). Also acceptable: Plain red, green (sodium heparin), lavender (EDTA), or pink (K2EDTA).
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Separator tubes. Plasma or whole blood collected in lt. blue (sodium citrate). Specimens exposed to repeated freeze/thaw cycles. Hemolyzed specimens.
After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years
Reference Interval
Effective August 17, 2015
Drugs Covered | Cutoff Concentrations |
Codeine | 2 ng/mL |
Morphine | 2 ng/mL |
6-acetylmorphine | 2 ng/mL |
Hydrocodone | 2 ng/mL |
Hydromorphone | 2 ng/mL |
Oxycodone | 2 ng/mL |
Oxymorphone | 2 ng/mL |
Interpretive Data
Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Positive cutoff: 2 ng/mL
For medical purposes only; not valid for forensic use.
Identification of specific drug(s) taken by specimen donor is problematic due to common metabolites, some of which are prescriptions drugs themselves. The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. All drugs covered are the non-glucuronidated (free) form. The concentration value must be greater than or equal to the cutoff to be reported as positive. A very small amount of an unexpected drug analyte in the presence of a large amount of an expected drug analyte may reflect pharmaceutical impurity. Interpretive questions should be directed to the laboratory.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
80361; 80365 (Alt code: G0480)
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2006559 | Hydrocodone, S/P, Quant | 3680-6 |
2006560 | Hydromorphone, S/P, Quant | 3683-0 |
2006561 | Codeine, S/P, Quant | 3506-3 |
2006562 | Morphine, S/P, Quant | 3827-3 |
2006563 | 6-acetylmorphine, S/P, Quant | 12788-6 |
2006564 | Oxycodone, S/P, Quant | 3893-5 |
2006565 | Oxymorphone, S/P, Quant | 60467-8 |
Aliases
- Codeine
- Codeine and Metabolite
- Dilaudid
- Heroin
- Hydrocodone and Metabolite
- Hydromorphone
- Morphine
- MS Contin
- Norco
- Opana
- Opiates Quantitation
- Oxycodone
- Oxycodone and Metabolite
- OxyContin
- Oxymorphone
- Pain Management
- Percocet
- Percodan
- Roxicet
- Roxiprin
- Tylox