Ordering Recommendation

Aid in differentiation of inflammatory bowel disease (IBD) from irritable bowel syndrome (IBS) and other functional disorders of the gastrointestinal (GI) system. Aid in monitoring IBD and prediction of relapse.

Mnemonic
CALPRO
Methodology

Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Stool.

Specimen Preparation

Transfer 5 g stool to an unpreserved stool transport vial (ARUP Supply #40910). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1 g)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Specimens in media or preservatives.

Remarks
Stability

Ambient: 11 days; Refrigerated: 11 days; Frozen: 1 year

Reference Interval

Effective August 15, 2016
50 µg/g or less: Normal
51-120 µg/g: Borderline elevated, test should be re-evaluated in 4-6 weeks.
121 µg/g or greater: Abnormal

Interpretive Data



No compliance statements are in use for this test.

Note

Fecal Calprotectin is an indicator of the presence of neutrophils in stool and is not specific for IBD. Other intestinal ailments including GI infections and colorectal cancer can result in elevated concentrations of calprotectin. The diagnosis of IBD cannot be established solely on the basis of a positive calprotectin result. Patients with IBD fluctuate between active and inactive stages of disease. Calprotectin results may also fluctuate. GI bleeding of as much as 100 mL per day will increase the fecal calprotectin concentration by only 15 µg/g.

Hotline History
N/A
CPT Codes

83993

Components
Component Test Code* Component Chart Name LOINC
0092304 Calprotectin, Fecal 38445-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Fecal Calprotectin
  • Stool Calprotectin
Calprotectin, Fecal (INACTIVE as of 08/17/20: Refer to 3002859 in the August Hotline)