Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
New York DOH Approval Status
24-hour or random urine. Refrigerate 24-hour specimen during collection.
Transport one 4 mL aliquot of urine. (Min: 1 mL) Record total volume and collection time interval on transport tube and test request form.
Room temperature specimens. Acidified specimens or specimens with preservatives.
Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 1 month
|Creatinine, Urine - per 24h||
|Cortisol/Cortisone Ratio||18 years and older: 0.15-0.50|
|Cortisol, Urine Free - ratio to CRT||
|Cortisol, Urine Free - per 24h||
Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Reference intervals for children are based on literature from Taylor R.L. et al., Validation of a High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Method for Urine Cortisol and Cortisone. Clinical Chemistry 2002; 48:1511-19.
*The ratio of the concentrations of cortisol to cortisone will not be evaluated if the cortisol concentration is less than 5 µg/L.
|Component Test Code*||Component Chart Name||LOINC|
|0020207||Creatinine, Urine - per volume||2161-8|
|0020208||Creatinine, Urine - per 24h||2162-6|
|0020581||Cortisone, Urine Free - per 24h||14044-2|
|0092087||Cortisol, Urine Free - per volume||34909-2|
|0092088||Cortisone, Urine Free - per volume||30072-3|
|0093443||Cortisone, Urine Free - ratio to CRT||30511-0|
|0093444||Cortisol, Urine Free - ratio to CRT||32009-3|
|0097224||Cortisol, Urine Free - per 24h||2147-7|
|2006310||Cortisol/Cortisone, Urine Interpretation||48767-8|