Icon

Time Sensitive
Ordering Recommendation

Used primarily to monitor response to rituximab therapy.

Mnemonic
CD20
Methodology

Flow Cytometry

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Green (sodium heparin). Also acceptable: Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Transport 5 mL whole blood.

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated. Specimen should be received within 48 hours of collection for optimal viable testing.

Unacceptable Conditions

Frozen specimens. Specimens greater than 48 hours old. Clotted or hemolyzed specimens.

Remarks

Provide CBC, Wright's stained smear (if available), clinical history, differential diagnosis, and any relevant pathology reports.

Stability

Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable

Reference Interval

By report

Interpretive Data

Refer to report.

Compliance Category

Analyte Specific Reagent (ASR)

Note

Monoclonal antibody-based therapies such as Rituximab that target the CD20 antigen, are being used to treat patients with a variety of B-cell lymphomas and leukemias, as well as in the treatment of some autoimmune disorders. The effectiveness of these therapies for B-cell lymphomas and leukemias requires that the B-cell leukemia or lymphoma cells express CD20. This test examines whether surface CD20 antigen expression can be identified on any B-cells present in the submitted specimen. This test will also identify CD19 antigen expression and the percentage of expression.

Hotline History
N/A
CPT Codes

88184; 88185; 88187

Components
Component Test Code* Component Chart Name LOINC
0095234 Interpretation 50595-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CD19
  • CD20 on B Cells
  • Rituximab Therapy CD20
B-Cell CD20 Expression