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Methadone and Metabolite, Serum or Plasma, Quantitative
Ordering Recommendation
Use to monitor patient adherence.
New York DOH Approval Status
Specimen Required
Gray (sodium fluoride/potassium oxalate). Also acceptable: Plain red, green (sodium heparin), lavender (EDTA), or pink (K2EDTA).
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP standard transport tube. (Min: 0.5 mL)
Refrigerated.
Separator tubes. Plasma or whole blood collected in lt. blue (sodium citrate). Specimens exposed to repeated freeze/thaw cycles. Hemolyzed specimens.
After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-7 days
Reference Interval
Effective August 17, 2015
| Drugs Covered | Cutoff Concentrations |
| Methadone | 10 ng/mL |
| EDDP | 10 ng/mL |
Interpretive Data
Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Positive cutoff: 10 ng/mL
For medical purposes only; not valid for forensic use.
The absence of expected drug(s) and/or drug metabolite(s) may indicate noncompliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.
Laboratory Developed Test (LDT)
Note
Hotline History
Hotline History
CPT Codes
80358 (Alt code: G0480)
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2005892 | Methadone, S/P, Quant | 3772-1 |
| 2005893 | EDDP, S/P, Quant | 60071-8 |
Aliases
- Amidone
- Dolophine
- EDDP
- Heptadon
- Methadone
- Methadose
- Symoron
- Pain Management
- Physeptone
