Ordering Recommendation

Preferred test to follow-up presumptive results. For general screening, Opiates, Urine Screen with Reflex to Quantitation (2005093) is preferred.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Random urine.

Specimen Preparation

Transfer 0.5 mL with no additives or preservatives urine to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Specimens exposed to repeated freeze/thaw cycles.


Ambient: 1 week; Refrigerated: 1 month; Frozen: 3 years


Quantitative Liquid Chromatography-Tandem Mass Spectrometry




1-4 days

Reference Interval

Effective August 17, 2015

Drugs Covered Cutoff Concentrations
Codeine 20 ng/mL
Morphine 20 ng/mL
6-acetylmorphine 10 ng/mL
Hydrocodone 20 ng/mL
Norhydrocodone 20 ng/mL
Hydromorphone 20 ng/mL
Oxycodone 20 ng/mL
Noroxycodone 20 ng/mL
Oxymorphone 20 ng/mL
Noroxymorphone 20 ng/mL

Interpretive Data

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Positive cutoff:
20 ng/mL except as specified below:
   6-acetylmorphine10 ng/mL

For medical purposes only; not valid for forensic use.

Identification of specific drug(s) taken by specimen donor is problematic due to common metabolites, some of which are prescription drugs themselves. The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. All drug analytes covered are in the non-glucuronidated (free) forms. The concentration value must be greater than or equal to the cutoff to be reported as positive. A very small amount of an unexpected drug analyte in the presence of a large amount of an expected drug analyte may reflect pharmaceutical impurity. Interpretive questions should be directed to the laboratory. 

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes

80361; 80365 (Alt code: G0480)


Component Test Code* Component Chart Name LOINC
2005092 Hydrocodone, Urn, Quant 16252-9
2005098 Oxycodone, Urn, Quant 16249-5
2005099 Oxymorphone, Urn, Quant 17395-5
2005222 Hydromorphone, Urn, Quant 16998-7
2005223 Codeine, Urn, Quant 16250-3
2005224 Morphine, Urn, Quant 16251-1
2005225 6-acetylmorphine, Urn, Quant 19593-3
2006968 Noroxycodone, Urn, Quant 61425-5
2006969 Noroxymorphone, Urn, Quant 90894-7
2008515 Norhydrocodone, Urn, Quant 61422-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • 6-Acetylmorphine
  • 6-AM
  • 6-MAM
  • Anexsia
  • Avinza
  • Codeine
  • Combunox
  • Depalgos
  • DepoDur
  • Diacetylmorphine
  • Diamorphine
  • Dicodid
  • Dihydromorphinone
  • Dilaudid
  • Dimorphone
  • Drocode
  • Duodin
  • Duramorph
  • Endocet
  • Exalgo
  • Heroin
  • Histinex
  • Hycet
  • Hycodan
  • Hycomine
  • Hycotuss
  • Hydrococet
  • Hydrocodone
  • Hydromet
  • Hydromorphone
  • Hydrovo
  • Kadian
  • Kolikodol
  • Laudicon
  • Loracet
  • Lortab
  • Mercodinone
  • Methylmorphine
  • Morphine
  • MS Contin
  • MS-Contin
  • Norco
  • Novahistex
  • Numorphan
  • Numorphone
  • Opana
  • Opium
  • Oramorph
  • Orthoxycol
  • Oxycodone
  • Oxymorphone
  • Pain Management
  • Pain Management, Opiates Expanded, Quantitative, with medMATCH, Urine
  • Pain Management, Oxycodone, Quantitative, with medMATCH, Urine
  • Palladone
  • Paracodeine
  • Paragoric
  • Parzone
  • Percocet
  • Percodan
  • Roxanol
  • Roxicet
  • Roxicodone
  • Roxiprin
  • Symtan
  • Synkonin
  • Targin
  • Tussionex
  • Tylox
  • Vicodin
  • Vicoprofen
  • Zydone
Opiates, Urine, Quantitative