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Tricyclic Antidepressant Detection
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Ordering Recommendation
Screening test for tricyclic antidepressants including amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, and trimipramine. Results are unconfirmed and are to be used for medical (treatment) purposes only.
Mnemonic
Methodology
Enzyme Immunoassay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
Specimen Required
Plain red.
Separate serum from cells within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Separator tubes.
After separation from cells: Ambient: 24 hours; Refrigerated: 1 month; Frozen: 1 year
Reference Interval
Negative
Interpretive Data
This test is positive when the total concentration of all detectable tricyclic antidepressants produces a response greater than the cutoff of 300 ng/mL nortriptyline. This is a screening test, results are unconfirmed. Unconfirmed results are to be used for medical (treatment) purposes only. Tricyclic antidepressants detectable with this assay include: amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, and trimipramine.
Levels of tricyclic antidepressants in the therapeutic range may not be detectable.
False-positive results may occur with the following drugs: Seroquel (quetiapine fumarate), Trileptal (oxcarbazepine), Benadryl (diphenhydramine) at toxic concentrations, Flexeril (cyclobenzaprine), Thioridazine, and Thorazine (chlorpromazine).
FDA
Note
Hotline History
CPT Codes
80307
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0090307 | Tricyclic Antidepressant Detection | 4073-3 |
Aliases
- amitriptyline
- desipramine
- domipramine
- doxepin
- imipramine
- nortriptyline
- protriptyline
- Tricyclic Antidepressants, Total, detection
- trimipramine
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