Ordering Recommendation

Use to optimize drug therapy and monitor patient adherence.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Timing of specimen collection: Predose (trough) draw - at steady state concentration.


Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP amber standard transport tube to protect from light. Freeze immediately (Min: 0.5 mL)

Storage/Transport Temperature

Critical Frozen. Additional specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution). Refrigerated or room temperature specimens.


After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 year


Quantitative Liquid Chromatography-Tandem Mass Spectrometry


Mon, Tue, Thu, Fri, Sat


1-7 days

Reference Interval

Therapeutic Range 0.5-2.0 µg/mL
Toxic Level Greater than 2.5 µg/mL

Interpretive Data

Toxic concentrations may exacerbate arrhythmias, cause liver and lung toxicity, and thyroid dysfunction. The concentration of desethylamiodarone, an active major metabolite, is also reported but no therapeutic range is established. At steady-state, the metabolite concentration is similar to the amiodarone concentration.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0090162 Amiodarone 3330-8
0090163 N-Desethyl-Amiodarone 6774-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Cordarone
  • Nexterone
  • Pacerone
Amiodarone and Metabolite