Ordering Recommendation

Optimize drug therapy and monitor patient adherence.




Quantitative Liquid Chromatography-Tandem Mass Spectrometry


Mon-Tue, Thu-Sat


1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - at steady state concentration.


Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).


After separation from cells: Ambient: 1 month; Refrigerated: 6 weeks; Frozen: 6 weeks

Reference Interval

Effective November 12, 2018

Therapeutic Range 0.5-2.0 µg/mL
Toxic Level Greater than 3.0 µg/mL

Interpretive Data

Toxic concentrations may exacerbate arrhythmias, cause liver and lung toxicity, and thyroid dysfunction. The concentration of desethylamiodarone, an active major metabolite, is also reported but no therapeutic range is established. At steady-state, the metabolite concentration is similar to the amiodarone concentration.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0090162 Amiodarone 3330-8
0090163 N-Desethyl-Amiodarone 6774-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


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Amiodarone and Metabolite