Optimize drug therapy and monitor patient adherence.
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Timing of specimen collection: Pre-dose (trough) draw - at steady state concentration.
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
After separation from cells: Ambient: 1 month; Refrigerated: 6 weeks; Frozen: 6 weeks
Effective November 12, 2018
|Therapeutic Range||0.5-2.0 µg/mL|
|Toxic Level||Greater than 3.0 µg/mL|
Toxic concentrations may exacerbate arrhythmias, cause liver and lung toxicity, and thyroid dysfunction. The concentration of desethylamiodarone, an active major metabolite, is also reported but no therapeutic range is established. At steady-state, the metabolite concentration is similar to the amiodarone concentration.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|