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Amiodarone and Metabolite
Copy Utility
Ordering Recommendation
Optimize drug therapy and monitor patient adherence.
Mnemonic
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Mon-Tue, Thu-Sat
Reported
1-4 days
New York DOH Approval Status
Specimen Required
Timing of specimen collection: Pre-dose (trough) draw - at steady state concentration.
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Refrigerated.
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
After separation from cells: Ambient: 1 month; Refrigerated: 6 weeks; Frozen: 6 weeks
Reference Interval
Effective November 12, 2018
| Therapeutic Range | 0.5-2.0 µg/mL |
| Toxic Level | Greater than 3.0 µg/mL |
Interpretive Data
Toxic concentrations may exacerbate arrhythmias, cause liver and lung toxicity, and thyroid dysfunction. The concentration of desethylamiodarone, an active major metabolite, is also reported but no therapeutic range is established. At steady-state, the metabolite concentration is similar to the amiodarone concentration.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
80151
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0090162 | Amiodarone | 3330-8 |
| 0090163 | N-Desethyl-Amiodarone | 6774-4 |
Aliases
- Cordarone
- Nexterone
- Pacerone
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