Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
AMIOD
Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Mon-Tue, Thu-Sat

Reported

1-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - at steady state concentration.

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Remarks
Stability

After separation from cells: Ambient: 1 month; Refrigerated: 6 weeks; Frozen: 6 weeks

Reference Interval

Effective November 12, 2018

Therapeutic Range 0.5-2.0 µg/mL
Toxic Level Greater than 3.0 µg/mL

Interpretive Data

Toxic concentrations may exacerbate arrhythmias, cause liver and lung toxicity, and thyroid dysfunction. The concentration of desethylamiodarone, an active major metabolite, is also reported but no therapeutic range is established. At steady-state, the metabolite concentration is similar to the amiodarone concentration.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

80299

Components
Component Test Code* Component Chart Name LOINC
0090162 Amiodarone 3330-8
0090163 N-Desethyl-Amiodarone 6774-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cordarone
  • Nexterone
  • Pacerone
Amiodarone and Metabolite