Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
DIAZ
Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Tue, Fri

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration

Collect

Gray (Potassium Oxalate/Sodium Fluoride). Also acceptable: Plain Red, Green (Sodium Heparin), Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Gel separator tubes. Plasma or whole blood collected in light blue (sodium citrate). Hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years (Avoid repeated freeze/thaw cycles)

Reference Interval

Dose-Related Range:

Test Number
Components
Dose-Related Range
  Diazepam Effective November 16, 2015
200-1000 ng/mL - Based on normal dosage amounts
  Nordiazepam Effective November 16, 2015
100-1500 ng/mL - Based on normal dosage amounts
Toxic: Greater than 2500 ng/mL

Interpretive Data

Adverse effects may include drowsiness, fatigue, ataxia and muscle weakness.

Compliance Category

Standard

Note
Hotline History
N/A
CPT Codes

80346 (Alt code: G0480)

Components
Component Test Code* Component Chart Name LOINC
0090075 Diazepam 3548-5
0090195 Nordiazepam 3537-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Benzodiazepines
  • Clorazepate
  • Diastat
  • Diazemuls
  • Diazepam and Metabolite
  • Nordiazepam
  • Stesolid
  • T-Quil
  • Tranxene
  • Valium
  • Valrelease
  • Zetran
Diazepam and Nordiazepam