Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
NORT HPLC
Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Mon, Wed, Fri

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

If amitriptyline is administered, order Amitriptyline and Nortriptyline (ARUP test code 0090158).  Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Remarks
Stability

After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months

Reference Interval

Therapeutic Range:
50-150 ng/mL
Toxic: > 500 ng/mL

Interpretive Data

Toxic concentrations may cause anticholinergic effects, cardiac abnormalities and seizures.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

80335 (Alt code: G0480)

Components
Component Test Code* Component Chart Name LOINC
0090074 Nortriptyline 3872-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Allegron
  • Aventyl
  • Noritren
  • Norpress
  • Nortrilen
  • Pamelor
  • Sensoval
  • TCA
  • Tricyclic Antidepressants
Nortriptyline