Clonazepam
Ordering Recommendation
Use to optimize dosing and monitor patient adherence.
New York DOH Approval Status
Specimen Required
Timing of specimen collection: Predose (trough) draw at steady state concentration
Gray (potassium oxalate/sodium fluoride). Also acceptable: Plain red, green (sodium heparin), lavender (K2 or K3EDTA) or pink (K2EDTA).
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP standard transport tube. (Min: 1 mL)
Refrigerated.
Gel separator tubes. Plasma or whole blood collected in light blue (sodium citrate). Hemolyzed specimens.
After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years (Avoid repeated freeze/thaw cycles).
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Tue, Fri
Reported
1-7 days
Reference Interval
Effective November 18, 2013
Dose-Related Range | 20-70 ng/mL - Dose (Adult) 1-8 mg/d |
Toxic | Greater than 80 ng/mL |
Interpretive Data
Adverse effects may include drowsiness, headache, fatigue, and ataxia.
Laboratory Developed Test (LDT)
Note
Hotline History
Hotline History
CPT Codes
80346 (Alt code: G0480)
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0090055 | Clonazepam | 3494-2 |
Aliases
- 340 Clonazepam
- Clonopin, S
- Klonopin
- Klonopin Wafers
- Nitrazepam
- Nitrozepane
- Rivotril