Methylmalonic Acid (MMA) Quantitative, Urine
Ordering Recommendation
Use to monitor patients with methylmalonic aciduria. Diagnosis of methylmalonic aciduria requires an organic acid panel and appropriate clinical history.
New York DOH Approval Status
Specimen Required
24-hour or random urine. Refrigerate 24-hour specimens during collection.
Transfer a 4 mL aliquot from a well-mixed 24-hour or random urine collection to an ARUP Standard Transport Tube and refrigerate or freeze immediately. (Min: 1 mL) Record total volume and collection time interval on transport tube and test request form.
Frozen.
Room temperature specimens.
Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 1 month
Methodology
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-3 days
Reference Interval
Test Number |
Components |
Reference Interval |
|||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Creatinine, Urine - per 24h |
|
||||||||||||||||||||||
MMA - ratio to CRT | 0.0-3.6 mmol/mol CRT |
Interpretive Data
Urinary methylmalonic acid, when increased, is an early and sensitive indicator of vitamin B12 (cobalamin) deficiency. This test can also be used to monitor patients with methylmalonic aciduria. Diagnosis of methylmalonic aciduria requires an organic acid panel and appropriate clinical history.
Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
83921
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0020207 | Creatinine, Urine - per volume | 2161-8 |
0020208 | Creatinine, Urine - per 24h | 2162-6 |
0083919 | MMA - per volume | 32287-5 |
0083920 | MMA - ratio to CRT | 25116-5 |
0097110 | Total Volume | 19153-6 |
0097111 | Hours Collected | 30211-7 |
2007350 | Methylmalonic Acid, Urine Interpretation | 48767-8 |