Use to monitor patients with methylmalonic aciduria. Diagnosis of methylmalonic aciduria requires an organic acid panel and appropriate clinical history.
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
24-hour or random urine. Refrigerate 24-hour specimens during collection.
Transfer a 4 mL aliquot from a well-mixed 24-hour or random urine collection to an ARUP Standard Transport Tube and refrigerate or freeze immediately. (Min: 1 mL) Record total volume and collection time interval on transport tube and test request form.
Room temperature specimens.
Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 1 month
|MMA - ratio to CRT||0.0-3.6 mmol/mol crt|
|0020473||Creatinine, Urine - per 24h||
Urinary methylmalonic acid, when increased, is an early and sensitive indicator of vitamin B12 (cobalamin) deficiency. This test can also be used to monitor patients with methylmalonic aciduria. Diagnosis of methylmalonic aciduria requires an organic acid panel and appropriate clinical history.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0020207||Creatinine, Urine - per volume||2161-8|
|0020208||Creatinine, Urine - per 24h||2162-6|
|0083919||MMA - per volume||32287-5|
|0083920||MMA - ratio to CRT||25116-5|
|2007350||Methylmalonic Acid, Urine Interpretation||19146-0|