May be used as a marker of severe combined immunodeficiency (SCID); lack of adenosine deaminase (ADA) allows deoxyadenosine to accumulate and kill lymphocytes.
Sun, Tue, Thu
Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).
Do not freeze. Transport 1 mL whole blood.
Ambient: 15 days; Refrigerated: 15 days; Frozen: Unacceptable
Effective August 20, 2012
400-900 mU/g Hb
Adenosine Deaminase (ADA) deficiency is an autosomal recessive disorder of purine metabolism primarily affecting lymphocyte development, viability, and function. Affected individuals have less than 1 percent of normal ADA catalytic activity in red cell hemolysates. ADA deficiency is the cause of 20-30 percent of SCID cases. If the patient has been recently transfused, ADA deficiency may be masked; interpret results with caution. Heterozygotes cannot be identified by this test.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0083001||Adenosine Deaminase RBC||47549-1|