Ordering Recommendation

Use to assess risk of preterm delivery in less than or equal to 7-14 days from time of sample collection at 24 weeks 0 days to 34 weeks 6 days gestation when there are signs and symptoms of early preterm labor in women with intact amniotic membranes and minimal cervical dilation (<3 cm). May also aid in the assessment of risk of preterm delivery in less than or equal to 34 weeks gestation when a cervicovaginal specimen is obtained during a routine office visit between 22 weeks 0 days and 30 weeks, 6 days gestation in women with a singleton gestation.

Mnemonic
FFN
Methodology

Semi-Quantitative Immunoassay/Immunosorbent

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Collect specimen prior to any activities or procedures that might disrupt the cervix, eg, coitus, digital cervical examination, vaginal ultrasound, collection of culture specimens, or pap smear.
Testing should not be performed if the patient has had sexual intercourse within 24 hours prior to the sampling time because semen present may increase the possibility of a false-positive result. Contamination with lubricants, soaps, or disinfectants may cause invalid test results.

Collect

Insert the polyester-tipped swab provided in the specimen collection kit into the vagina and lightly rotate across the posterior fornix for approximately 10 seconds to absorb cervicovaginal secretions. Carefully remove the swab and place into the tube of buffer provided in the kit. Use only one specimen collection device per patient.

Specimen Preparation

Specimens that are not tested within eight hours of collection must be stored, refrigerated, and tested within 72 hours of collection. Avoid extreme temperatures. Transport swab in Fetal Fibronectin Specimen Collection Kit (ARUP supply #32748). Available online through eSupply using ARUP Connect™ or contact Client Services at (800) 522-2787.  Required Information: Specimen must be labeled with gestational age and list patient condition as either "symptomatic" or "asymptomatic."

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Specimens collected in or by any specimen device other than Fetal Fibronectin Specimen Collection Kit, visible evidence of moderate or gross vaginal bleeding. Specimens from symptomatic patients who are less than 24 weeks or greater than or equal to 35 weeks gestation. Specimens from asymptomatic patients who are less than 22 weeks or greater than or equal to 35 weeks gestation.

Remarks
Stability

Ambient: 8 hours; Refrigerated: 3 days; Frozen: 2 weeks Only one freeze/thaw cycle acceptable.

Reference Interval
Interpretive Data

Among symptomatic women, a positive result obtained between 24 weeks, 0 days and 34 weeks, 6 days indicates increased risk of delivery in less than or equal to 7-14 days from sample collection.

Among asymptomatic women, a positive result between 22 weeks, 0 days and 30 weeks, 6 days indicates increased risk of delivery in less than or equal to 34 weeks, 6 days of gestation.

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

82731

Components
Component Test Code* Component Chart Name LOINC
0081024 Gestation Age in Wks and Days 49051-6
0081025 Labor Symptoms 57069-7
0082026 fFN Labor Symptoms 57069-7
0082027 fFN Gestational Age
0082028 fFN Interpretation 48039-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • FFN
Fetal Fibronectin