Ordering Recommendation

Surveillance and monitoring of hepatocellular carcinoma.

Mnemonic
AFP L3
Methodology

Quantitative Liquid Chromatography/Immunoassay

Performed

Mon,Thu

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Plasma.

Remarks
Stability

After separation from cells: Ambient: 8 hours; Refrigerated: 5 days; Frozen: 3 months (avoid repeated freeze/thaw cycles)

Reference Interval

By report

Test Number
Components
Reference Interval
  Alpha Fetoprotein Total 0-15 ng/mL
  Alpha Fetoprotein L3 Pct 0-9.9 percent

Interpretive Data

The µTASWako method is used. Results obtained with different assay methods or kits cannot be used interchangeably. The AFP L3 Percent assay is intended as a risk assessment for the development of hepatocellular carcinoma in patients with chronic liver diseases. Patients with elevated serum AFP-L3 percent should be more intensely evaluated for evidence of hepatocellular carcinoma since elevated values have been shown to be associated with a seven-fold increase in the risk for developing hepatocellular carcinoma within 21 months. Results cannot be interpreted as absolute evidence of the presence or absence of malignant disease. For pregnant females, the result is not interpretable as a tumor marker.

No compliance statements are in use for this test.

Note
Hotline History
N/A
CPT Codes

82107

Components
Component Test Code* Component Chart Name LOINC
0081207 Alpha Fetoprotein Total 1834-1
0081209 Alpha Fetoprotein L3 Pct 42332-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • AFP
  • AFP-L3%
  • Alpha Fetoprotein
  • Alpha Fetoprotein, Total and L3 Percent
  • Alpha-Fetoprotein (AFP) L3% and Total, Hepatocellular Carcinoma Tumor Marker, Serum
  • Alpha-fetoprotein, Total
  • Hepatocellular Carcinoma AFP
  • Total AFP
Alpha Fetoprotein, Total and L3 Percent