Ordering Recommendation

Use for nutritional assessment of vitamin A (retinol and retinyl palmitate) in serum or plasma.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Patient should fast for 12 hours and abstain from alcohol for 24 hours prior to collection.


Green (sodium or lithium heparin), plasma separator tube, or serum separator tube. Also acceptable: Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma within 1 hour of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube immediately. (Min: 0.2 mL) Avoid hemolysis.

Storage/Transport Temperature


Unacceptable Conditions

Whole blood or body fluids other than serum or plasma.


After separation from cells: Ambient: 3 hours; Refrigerated: 1 month; Frozen: 1 year


Quantitative High Performance Liquid Chromatography (HPLC)




1-4 days

Reference Interval

Test Number
Reference Interval
  Vitamin A (Retinol)
Reference Interval
0-1 month
2 months-12 years
13-17 years
18 years and older
0.18-0.50 mg/L
0.20-0.50 mg/L
0.26-0.70 mg/L
0.30-1.20 mg/L

  Vitamin A (Retinyl Palmitate) 0-150 years: 0-0.10 mg/L

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Serum retinol is typically maintained until hepatic stores are almost depleted. Values greater than 0.30 mg/L represent adequate liver stores, whereas values less than 0.10 mg/L indicate deficiency. Samples that come in contact with plastic tubing or have been exposed to excessive light may show low results.

Vitamin A toxicity occurs when retinol concentration exceeds the capacity of retinol binding protein (RBP). Individuals with compromised renal function can retain RBP and may, therefore, have moderate retinol elevations. Drugs which interfere with vitamin A analysis include probucol (Lorelco).

This assay does not measure other vitamin A metabolites such as retinaldehyde and retinoic acid.

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0080375 Vitamin A (Retinol) 2923-1
0080523 Vitamin A, Ser/Pla - Interpretation 48767-8
0080524 Vitamin A (Retinyl Palmitate) 38496-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • A Vitamin
  • Retinol
  • Retinyl palmitate
Vitamin A (Retinol), Serum or Plasma