Ordering Recommendation

Evaluate and monitor ovarian cancer, usually epithelial subtype. Not recommended for monitoring breast cancer or germ tumors. Not a stand-alone test for ovarian cancer screening or diagnosis.

Mnemonic
CA125
Methodology

Quantitative Electrochemiluminescent Immunoassay

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plasma separator tube or serum separator tube. Also acceptable: Green (sodium or lithium heparin), lavender (EDTA), or pink (K2EDTA).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Grossly hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: 5 days; Refrigerated: 5 days; Frozen: 2 years

Reference Interval

0-35 U/mL

Interpretive Data

The Roche CA 125 electrochemiluminescent immunoassay is used. Results obtained with different test methods or kits cannot be used interchangeably. The CA 125 test is used as an aid in monitoring response to therapy for patients with epithelial ovarian cancer. Serial testing for patient CA 125 values should be used in conjunction with other clinical methods for monitoring ovarian cancer. Patients with confirmed ovarian carcinoma may have pretreatment CA 125 values in the same range as healthy individuals. Elevations may be observed in patients with nonmalignant disease. Therefore, a CA 125 value, regardless of level, should not be interpreted as absolute evidence of the presence or absence of malignant disease.

No compliance statements are in use for this test.

Note
Hotline History
N/A
CPT Codes

86304

Components
Component Test Code* Component Chart Name LOINC
0080462 Cancer Antigen 125 10334-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CA 125
  • CA 125 Tumor Marker
  • CA-125 tumor marker
  • CA125
  • CA125 concentration
  • CA125 levels
  • Cancer Ag 125
  • Cancer antigen 125
  • Carbohydrate Antigen 125
  • OV Monitor
  • Ovarian Cancer-Related Antibodies
Cancer Antigen 125