Ordering Recommendation

Initial test to diagnose or rule out Ehlers-Danlos Syndrome, Type VI A (kyphoscoliotic type). This testing is NOT recommended to screen for other types of EDS.

Mnemonic
EDS6
Methodology

High Performance Liquid Chromatography (HPLC)

Performed

Wed

Reported

6-14 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

First-morning urine is preferred.

Collect

Urine. First-morning void. Also acceptable: Random specimens.

Specimen Preparation

Transfer 4 mL urine to an ARUP Standard Transport Tube. (Min: 3 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions
Remarks
Stability

Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 6 months

Reference Interval
Age
PYR
DPYR
Ratio DPYR/PYR
0-11 months Not applicable Not applicable 0.13-0.20
1-3 years Not applicable Not applicable 0.18-0.24
4-9 years Not applicable Not applicable 0.19-0.25
10-14 years Not applicable Not applicable 0.17-0.27
15-19 years Not applicable Not applicable 0.20-0.26
20 years and older Not applicable Not applicable 0.23-0.29

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

For pyridinoline and deoxypyridinoline quantitative results, order Pyridinoline & Deoxypyridinoline by HPLC (0080342).

Hotline History
N/A
CPT Codes

82523

Components
Component Test Code* Component Chart Name LOINC
0080352 Pyridinoline, pmol/mL 34367-3
0080353 Deoxypyridinoline, pmol/mL 27424-1
0080354 EDS6 Ratio
0080357 EDS6 Interpretation 56850-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • EDS VI
  • pyridinoline and deoxypyridnoline
Ehlers-Danlos Syndrome Type VI Screen