Ordering Recommendation
Initial test to diagnose or rule out Ehlers-Danlos Syndrome, Type VI A (kyphoscoliotic type). This testing is NOT recommended to screen for other types of EDS.
Mnemonic
Methodology
High Performance Liquid Chromatography (HPLC)
Performed
Wed
Reported
6-14 days
New York DOH Approval Status
Specimen Required
First-morning urine is preferred.
Urine. First-morning void. Also acceptable: Random specimens.
Transfer 4 mL urine to an ARUP Standard Transport Tube. (Min: 3 mL)
Frozen.
Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 6 months
Reference Interval
Age |
PYR |
DPYR |
Ratio DPYR/PYR |
---|---|---|---|
0-11 months | Not applicable | Not applicable | 0.13-0.20 |
1-3 years | Not applicable | Not applicable | 0.18-0.24 |
4-9 years | Not applicable | Not applicable | 0.19-0.25 |
10-14 years | Not applicable | Not applicable | 0.17-0.27 |
15-19 years | Not applicable | Not applicable | 0.20-0.26 |
20 years and older | Not applicable | Not applicable | 0.23-0.29 |
Interpretive Data
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
For pyridinoline and deoxypyridinoline quantitative results, order Pyridinoline & Deoxypyridinoline by HPLC (0080342).
Hotline History
CPT Codes
82523
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0080352 | Pyridinoline, pmol/mL | 34367-3 |
0080353 | Deoxypyridinoline, pmol/mL | 27424-1 |
0080354 | EDS6 Ratio | 58955-6 |
0080357 | EDS6 Interpretation | 56850-1 |
Aliases
- EDS VI
- pyridinoline and deoxypyridnoline