Ordering Recommendation

Initial test to diagnose or rule out Ehlers-Danlos Syndrome, Type VI A (kyphoscoliotic type). This testing is NOT recommended to screen for other types of EDS.

Mnemonic
EDS6
Methodology

High Performance Liquid Chromatography (HPLC)

Performed

Wed

Reported

6-14 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

First-morning urine is preferred.

Collect

Urine. First-morning void. Also acceptable: Random specimens.

Specimen Preparation

Transfer 4 mL urine to an ARUP Standard Transport Tube. (Min: 3 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions
Remarks
Stability

Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 6 months

Reference Interval
Age
PYR
DPYR
Ratio DPYR/PYR
0-11 months Not applicable Not applicable 0.13-0.20
1-3 years Not applicable Not applicable 0.18-0.24
4-9 years Not applicable Not applicable 0.19-0.25
10-14 years Not applicable Not applicable 0.17-0.27
15-19 years Not applicable Not applicable 0.20-0.26
20 years and older Not applicable Not applicable 0.23-0.29

Interpretive Data



Compliance Category

Laboratory Developed Test (LDT)

Note

For pyridinoline and deoxypyridinoline quantitative results, order Pyridinoline & Deoxypyridinoline by HPLC (0080342).

Hotline History
N/A
CPT Codes

82523

Components
Component Test Code* Component Chart Name LOINC
0080352 Pyridinoline, pmol/mL 34367-3
0080353 Deoxypyridinoline, pmol/mL 27424-1
0080354 EDS6 Ratio
0080357 EDS6 Interpretation 56850-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • EDS VI
  • pyridinoline and deoxypyridnoline
Ehlers-Danlos Syndrome Type VI Screen