Ordering Recommendation

Diagnostic evaluation of patients suspected to have collagen lysyl hydroxylase deficiency (Ehlers-Danlos Syndrome type VIA). May be useful when evaluating bone resorption (eg, osteoporosis). Preferred test for monitoring bone resorption and response to antiresorptive therapy is C-Telopeptide, Beta-Cross-Linked, Serum (0070416).

Mnemonic
PYD & DPD
Methodology

High Performance Liquid Chromatography (HPLC)

Performed

Wed

Reported

6-14 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

First morning void.

Collect

Urine.

Specimen Preparation

Transfer 8 mL urine to ARUP Standard Transport Tubes. (Min: 4 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Random urine.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 6 months

Reference Interval

Age
PYR
µmol/mol creatinine
DPYR
µmol/mol creatinine

DPYR/PYR Ratio
0-11 months 353-560 µmol/mol crt 46-113 µmol/mol crt 0.13-0.20
1-3 years 108-400 µmol/mol crt 19-94 µmol/mol crt 0.18-0.24
4-9 years 117-325 µmol/mol crt 20-75 µmol/mol crt 0.19-0.25
10-14 years 81-267 µmol/mol crt 13-61 µmol/mol crt 0.17-0.27
15-19 years 38-80 µmol/mol crt 10-18 µmol/mol crt 0.20-0.26
20 years and older 20-40 µmol/mol crt 5-11 µmol/mol crt 0.23-0.29

Interpretive Data

Pyridinoline and Deoxypyridinoline excretion follows a circadian rhythm.  Reference intervals have been established on first morning void urine samples.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
N/A
CPT Codes

82523

Components
Component Test Code* Component Chart Name LOINC
0080343 Pyridinoline 25129-8
0080344 Deoxypyridinoline 25095-1
0080346 DPYR/PYD Ratio 58954-9
0080347 PYD and DPD Interpretation
3002333 Creatinine, Urine
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Deoxypyridinoline and Pyridinoline, HPLC
Pyridinoline and Deoxypyridinoline by HPLC