Ordering Recommendation

Diagnostic evaluation of patients suspected to have collagen lysyl hydroxylase deficiency (Ehlers-Danlos Syndrome type VIA). May be useful when evaluating bone resorption (eg, osteoporosis). Preferred test for monitoring bone resorption and response to antiresorptive therapy is C-Telopeptide, Beta-Cross-Linked, Serum (0070416).

Mnemonic
PYD & DPD
Methodology

High Performance Liquid Chromatography (HPLC)

Performed

Wed

Reported

6-14 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

First morning void.

Collect

Urine.

Specimen Preparation

Transfer 8 mL urine to ARUP Standard Transport Tubes. (Min: 4 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Random urine.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 6 months

Reference Interval

Age
PYR
µmol/mol creatinine
DPYR
µmol/mol creatinine

DPYR/PYR Ratio
0-11 months 353-560 µmol/mol crt 46-113 µmol/mol crt 0.13-0.20
1-3 years 108-400 µmol/mol crt 19-94 µmol/mol crt 0.18-0.24
4-9 years 117-325 µmol/mol crt 20-75 µmol/mol crt 0.19-0.25
10-14 years 81-267 µmol/mol crt 13-61 µmol/mol crt 0.17-0.27
15-19 years 38-80 µmol/mol crt 10-18 µmol/mol crt 0.20-0.26
20 years and older 20-40 µmol/mol crt 5-11 µmol/mol crt 0.23-0.29

Interpretive Data

Pyridinoline and Deoxypyridinoline excretion follows a circadian rhythm.  Reference intervals have been established on first morning void urine samples.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

82523

Components
Component Test Code* Component Chart Name LOINC
0080343 Pyridinoline 25129-8
0080344 Deoxypyridinoline 25095-1
0080346 DPYR/PYD Ratio 58954-9
0080347 PYD and DPD Interpretation
3002333 Creatinine, Urine
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Deoxypyridinoline and Pyridinoline, HPLC
Pyridinoline and Deoxypyridinoline by HPLC