Pyridinoline and Deoxypyridinoline by HPLC

0080342
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Additional Technical Information

Ordering Recommendation

Diagnostic evaluation of patients suspected to have collagen lysyl hydroxylase deficiency (Ehlers-Danlos Syndrome type VIA). May be useful when evaluating bone resorption (eg, osteoporosis). Preferred test for monitoring bone resorption and response to antiresorptive therapy is C-Telopeptide, Beta-Cross-Linked, Serum (0070416).

Mnemonic

PYD & DPD

Methodology

High Performance Liquid Chromatography (HPLC)

Performed

Wed

Reported

6-14 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

First morning void.

Collect

Urine.

Specimen Preparation

Transfer 8 mL urine to ARUP Standard Transport Tubes. (Min: 4 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Random urine.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 6 months

Reference Interval


Age
 PYR
µmol/mol creatinine
 DPYR
µmol/mol creatinine
DPYR/PYR Ratio
0-11 months 353-560 µmol/mol crt 46-113 µmol/mol crt 0.13-0.20
1-3 years 108-400 µmol/mol crt 19-94 µmol/mol crt 0.18-0.24
4-9 years 117-325 µmol/mol crt 20-75 µmol/mol crt 0.19-0.25
10-14 years 81-267 µmol/mol crt 13-61 µmol/mol crt 0.17-0.27
15-19 years 38-80 µmol/mol crt 10-18 µmol/mol crt 0.20-0.26
20 years and older 20-40 µmol/mol crt 5-11 µmol/mol crt 0.23-0.29

Interpretive Data

Pyridinoline and Deoxypyridinoline excretion follows a circadian rhythm.  Reference intervals have been established on first morning void urine samples.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

82523

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Components

Component Test Code* Component Chart Name LOINC
0080343 Pyridinoline 25129-8
0080344 Deoxypyridinoline 25095-1
0080346 DPYR/PYD Ratio 58954-9
0080347 PYD and DPD Interpretation
3002333 Creatinine, Urine
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Deoxypyridinoline and Pyridinoline, HPLC
Pyridinoline and Deoxypyridinoline by HPLC