Ordering Recommendation
Diagnostic evaluation of patients suspected to have collagen lysyl hydroxylase deficiency (Ehlers-Danlos Syndrome type VIA). May be useful when evaluating bone resorption (eg, osteoporosis). Preferred test for monitoring bone resorption and response to antiresorptive therapy is C-Telopeptide, Beta-Cross-Linked, Serum (0070416).
Mnemonic
Methodology
High Performance Liquid Chromatography (HPLC)
Performed
Wed
Reported
6-14 days
New York DOH Approval Status
Specimen Required
First morning void.
Urine.
Transfer 8 mL urine to ARUP Standard Transport Tubes. (Min: 4 mL)
Frozen.
Random urine.
Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 6 months
Reference Interval
Age |
PYR µmol/mol creatinine |
DPYR µmol/mol creatinine |
DPYR/PYR Ratio |
---|---|---|---|
0-11 months | 353-560 µmol/mol crt | 46-113 µmol/mol crt | 0.13-0.20 |
1-3 years | 108-400 µmol/mol crt | 19-94 µmol/mol crt | 0.18-0.24 |
4-9 years | 117-325 µmol/mol crt | 20-75 µmol/mol crt | 0.19-0.25 |
10-14 years | 81-267 µmol/mol crt | 13-61 µmol/mol crt | 0.17-0.27 |
15-19 years | 38-80 µmol/mol crt | 10-18 µmol/mol crt | 0.20-0.26 |
20 years and older | 20-40 µmol/mol crt | 5-11 µmol/mol crt | 0.23-0.29 |
Interpretive Data
Pyridinoline and Deoxypyridinoline excretion follows a circadian rhythm. Reference intervals have been established on first morning void urine samples.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
82523
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0080343 | Pyridinoline | 25129-8 |
0080344 | Deoxypyridinoline | 25095-1 |
0080346 | DPYR/PYD Ratio | 58954-9 |
0080347 | PYD and DPD Interpretation | |
3002333 | Creatinine, Urine |
Aliases
- Deoxypyridinoline and Pyridinoline, HPLC