Porphobilinogen (PBG), Urine

0080260
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Abnormal
Normal

Ordering Recommendation

Essential first-line test for suspected acute porphyria in adults. Use in determining metabolic response to IV hematin.

Mnemonic

PBGQT

Methodology

Quantitative Ion Exchange Chromatography/Spectrophotometry

Performed

Mon-Fri

Reported

1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Random or 24-hour urine. Refrigerate 24-hour specimens during collection.

Specimen Preparation

Protect from light. Transfer 8 mL aliquot from a random or well-mixed 24-hour collection to ARUP Amber Transport Tubes. (Min: 3.5 mL) Record total volume and collection time interval on transport tube and test request form.

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Body fluids other than urine.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 4 days; Frozen: 1 month

Reference Interval

Test Number
 Components
 Reference Interval
  Porphobilinogen (PBG), Urine -per volume 0.0-8.8 µmol/L
  Porphobilinogen, Urine - per 24h 0.0-11.0 µmol/d
0020473 Creatinine, Urine - per 24h
Age
 Male
 Female
3-8 years 140-700 mg/d 140-700 mg/d
9-12 years 300-1300 mg/d 300-1300 mg/d
13-17 years 500-2300 mg/d 400-1600 mg/d
18-50 years 1000-2500 mg/d 700-1600 mg/d
51-80 years 800-2100 mg/d 500-1400 mg/d
81 years and older 600-2000 mg/d 400-1300 mg/d

Interpretive Data

Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Appropriate test to rule out acute intermittent porphyria (AIP) and other acute attack types of porphyrias associated with neurologic and/or psychiatric symptoms.

Hotline History

N/A

CPT Codes

84110

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Components

Component Test Code* Component Chart Name LOINC
0020207 Creatinine, Urine - per volume 2161-8
0020208 Creatinine, Urine - per 24h 2162-6
0080261 Porphobilinogen, Urine - per 24h 14882-5
0080262 Porphobilinogen (PBG), Urine -per volume 2811-8
0097110 Total Volume 19153-6
0097111 Hours Collected 30211-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • PBG, Quantitative
  • Porphobilinogen
  • Watson-Schwartz Test
Porphobilinogen (PBG), Urine