Ordering Recommendation

Essential first-line test for suspected acute porphyria in adults. Use in determining metabolic response to IV hematin.

Mnemonic
PBGQT
Methodology

Quantitative Ion Exchange Chromatography/Spectrophotometry

Performed

Mon-Fri

Reported

1-4 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Random or 24-hour urine. Refrigerate 24-hour specimens during collection.

Specimen Preparation

Protect from light. Transfer 8 mL aliquot from a random or well-mixed 24-hour collection to ARUP Amber Transport Tubes. (Min: 3.5 mL) Record total volume and collection time interval on transport tube and test request form.

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Body fluids other than urine.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 4 days; Frozen: 1 month

Reference Interval
Test Number
Components
Reference Interval
  Porphobilinogen (PBG), Urine -per volume 0.0-8.8 µmol/L
  Porphobilinogen, Urine - per 24h 0.0-11.0 µmol/d
0020473 Creatinine, Urine - per 24h
Age
Male
Female
3-8 years 140-700 mg/d 140-700 mg/d
9-12 years 300-1300 mg/d 300-1300 mg/d
13-17 years 500-2300 mg/d 400-1600 mg/d
18-50 years 1000-2500 mg/d 700-1600 mg/d
51-80 years 800-2100 mg/d 500-1400 mg/d
81 years and older 600-2000 mg/d 400-1300 mg/d

Interpretive Data



Compliance Category

Laboratory Developed Test (LDT)

Note

Appropriate test to rule out acute intermittent porphyria (AIP) and other acute attack types of porphyrias associated with neurologic and/or psychiatric symptoms.

Hotline History
N/A
CPT Codes

84110

Components
Component Test Code* Component Chart Name LOINC
0020207 Creatinine, Urine - per volume 2161-8
0020208 Creatinine, Urine - per 24h 2162-6
0080261 Porphobilinogen, Urine - per 24h 14882-5
0080262 Porphobilinogen (PBG), Urine -per volume 2811-8
0097110 Total Volume 19153-6
0097111 Hours Collected 30211-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • PBG, Quantitative
  • Porphobilinogen
  • Watson-Schwartz Test
Porphobilinogen (PBG), Urine