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Glucose-6-Phosphate Dehydrogenase
Ordering Recommendation
Preferred initial screening test for G6PD deficiency. For genetic testing in individuals of African descent, refer to Glucose-6-Phosphate Dehydrogenase (G6PD) 2 Mutations (0051684); for genetic testing in individuals with other high-risk ethnic backgrounds, refer to Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD) Sequencing (3004457).
Methodology
Quantitative Enzymatic Assay
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
Specimen Required
Yellow (ACD solution A). Also acceptable: Green (sodium or lithium heparin), lavender (K2EDTA or K3EDTA), or pink (K2EDTA). Enzyme most stable in acid citrate dextrose (ACD).
Do not freeze. Transport 3 mL whole blood. (Min: 1.5 mL heparin and EDTA collection tubes; Min: 0.5 mL pediatric collection tubes).
Refrigerated.
Clotted, frozen, or hemolyzed specimens.
Pediatric minimum 0.5 mL if collected and transported in a pediatric collection K2EDTA tube. ACD collection tubes should be filled to maximum collectible volume and are not recommended for pediatric specimen collection or preservation.
Ambient: 8 hours; Refrigerated: 1 week; Frozen: Unacceptable
Reference Interval
Effective November 17, 2014
9.9-16.6 U/g Hb
Interpretive Data
FDA
Note
Patients who have recently received transfusions have normal donor cells that may mask G-6-PD deficient erythrocytes.
Hotline History
CPT Codes
82955
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0080135 | Glucose-6-Phosphate Dehydrogenase | 32546-4 |
Aliases
- G-6-PD
- G6PD Erythrocytes
- RBC G6PD test
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