Evaluate suspected aminolevulinic acid dehydratase deficiency (ADP) porphyria or hereditary tyrosinemia.
Quantitative Ion Exchange Chromatography/Spectrophotometry
Mon, Wed, Fri
Refrain from alcohol consumption 24 hours prior to collection.
24 hour or random urine. Refrigerate 24-hour specimens during collection.
Transfer a 4 mL aliquot from a well-mixed 24 hour or random collection to an ARUP Standard Transport Tube. (Min: 1.2 mL)
Body fluids other than urine.
Record total volume and collection time interval on transport tube and test request form.
Ambient: Unacceptable; Refrigerated: 4 days; Frozen: 1 month
|Aminolevulinic Acid - per volume||0-35 µmol/L|
|Aminolevulinic Acid - per 24h||0-60 µmol/d|
|Creatinine, Urine - per 24h||
Increased ALA concentration is associated with exposure to alcohol, lead, and a variety of other agents. Massive elevation of ALA occurs in the acute porphyrias and hereditary tyrosinemia.
Specimen preservation with acid or base is discouraged and may cause assay interference. When collecting urine for additional tests that require acid or base preservation, the ALA aliquot should be removed prior to the addition of the acid or base.
|Component Test Code*||Component Chart Name||LOINC|
|0020207||Creatinine, Urine - per volume||2161-8|
|0020208||Creatinine, Urine - per 24h||2162-6|
|0080104||Aminolevulinic Acid - per volume||34284-0|
|0080105||Aminolevulinic Acid - per 24h||14689-4|
- 5-Aminolevulinic Acid
- Delta-Aminolevulinic Acid