Ordering Recommendation
Preferred test to measure bone resorption and monitor response to antiresorptive therapy (eg, bisphosphonates, hormone replacement therapy) in postmenopausal women and individuals with osteoporosis.
Mnemonic
Methodology
Quantitative Electrochemiluminescent Immunoassay
Performed
Sun - Sat
Reported
Within 24 hours
New York DOH Approval Status
Specimen Required
Fasting specimen preferred.
Serum/plasma separator tube, lavender (K2 EDTA or K3 EDTA), pink (K2 EDTA), or green (lithium heparin). A morning specimen is preferred.
Allow serum separator tube to sit for 15-20 minutes at room temperature for proper clot formation. Centrifuge and separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Hemolyzed specimens.
After separation from cells: Ambient: 4 hours; Refrigerated: 8 hours; Frozen: 3 months
Reference Interval
Effective May 16, 2022
Age |
Female |
Male |
---|---|---|
6 months-6 years | 500-1800 pg/mL | 238-1019 pg/mL |
7-9 years | 566-1690 pg/mL | 238-1019 pg/mL |
10-12 years | 503-2077 pg/mL | 238-1019 pg/mL |
13-15 years | 160-1590 pg/mL | 238-1019 pg/mL |
16-17 years | 167-933 pg/mL | 238-1019 pg/mL |
18-29 years | 238-1019 pg/mL | |
30-39 years | 225-936 pg/mL | |
40-49 years | 182-801 pg/mL | |
50-59 years | 161-737 pg/mL | |
60-69 years | 132-752 pg/mL | |
70 years or greater | 118-776 pg/mL | |
Premenopausal | 136-689 pg/mL | |
Postmenopausal | 177-1015 pg/mL |
Interpretive Data
FDA
Note
Hotline History
Hotline History
CPT Codes
82523
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0070415 | C-Telopeptide, Beta-Cross-Linked, Serum | 41171-0 |
Aliases
- Beta-CTx
- B-Cross Laps
- B-CTx
- Beta-Cross Laps
- bone resorption marker
- C-Telopeptide
- C-terminal collagen crosslinks
- Carboxy terminal collagen crosslinks
- Collagen C Telopeptide
- Collagen Type I-C
- Collagen Type I-C Telopeptide
- CTx