Ordering Recommendation
Aids in the detection of insulinoma. Do not use to diagnose diabetes mellitus.
Mnemonic
Methodology
Quantitative Chemiluminescent Immunoassay/Quantitative Chemiluminescent Immunoassay
Performed
Refer to individual components
Reported
1-6 days
New York DOH Approval Status
Specimen Required
Patient must be fasting for 12-15 hours prior to collection.
Serum Separator Tube (SST). Also acceptable: Lavender (K2EDTA) or Pink (K2EDTA).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.8 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Heparinized plasma. Vitreous or I.V. fluids. Hemolyzed specimens.
After separation from cells: Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: 2 months (avoid repeated freeze/thaw cycles)
Reference Interval
Available Separately |
Component |
Reference Interval |
---|---|---|
Yes (0070063) | Insulin, Fasting | 3-19 µIU/mL |
Yes (0070112) | Proinsulin, Intact | 0-17 years: Not established Effective May 19th, 2014 18 years and older: Less than or equal to 8.0 pmol/L |
No | Proinsulin, Intact/Insulin Ratio Calculation | Proinsulin, Intact/Insulin Ratio as Percent: 0-17 years: Not established 18 years and older: 0.8-21.7 percent |
Interpretive Data
Insulin, Fasting: This test reacts on a nearly equimolar basis with the analogs insulin aspart, insulin glargine, and insulin lispro. Insulin detemir exhibits approximately 50 percent cross-reactivity. Test reactivity with insulin glulisine is negligible (less than 3 percent). To convert to pmol/L, multiply µIU/mL by 6.0.
Proinsulin, Intact: Fasting intact proinsulin values above the reference interval indicate a possible insulin secreting pancreatic tumor (insulinoma) in patients with hypoglycemia. Fasting intact proinsulin values range from 3 to 50 pmol/L in patients with untreated type 2 diabetes.
FDA
Note
Hotline History
Hotline History
CPT Codes
84206; 83525
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0070063 | Insulin, Fasting | 27873-9 |
0070112 | Proinsulin, Intact | 10451-3 |
0070257 | Proinsulin, Intact/Insulin Ratio Calc |