Ordering Recommendation
Aids in the detection of insulinoma. Do not use to diagnose diabetes mellitus.
Mnemonic
Methodology
Quantitative Chemiluminescent Immunoassay/Quantitative Chemiluminescent Immunoassay
Performed
Tue, Thu
Reported
1-6 days
New York DOH Approval Status
Specimen Required
Patient must be fasting for 12-15 hours prior to collection.
Serum Separator Tube (SST).
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.8 mL)
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Heparinized plasma. Vitreous or I.V. fluids. Hemolyzed specimens.
After separation from cells: Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: 2 months (avoid repeated freeze/thaw cycles)
Reference Interval
Test Number |
Components |
Reference Interval |
||||||
---|---|---|---|---|---|---|---|---|
Insulin, Fasting | 3-25 µIU/mL | |||||||
Proinsulin, Intact |
|
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Proinsulin, Intact/Insulin Ratio Calc |
|
Interpretive Data
Insulin, Fasting: This test reacts on a nearly equimolar basis with the analogs insulin aspart, insulin glargine, and insulin lispro. Insulin detemir exhibits approximately 50 percent cross-reactivity. Test reactivity with insulin glulisine is negligible (less than 3 percent). To convert to pmol/L, multiply µIU/mL by 6.0.
Proinsulin, Intact: Fasting intact proinsulin values above the reference interval indicate a possible insulin secreting pancreatic tumor (insulinoma) in patients with hypoglycemia. Fasting intact proinsulin values range from 3 to 50 pmol/L in patients with untreated type 2 diabetes.
FDA
Note
Hotline History
Hotline History
CPT Codes
84206; 83525
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0070063 | Insulin, Fasting | 27873-9 |
0070112 | Proinsulin, Intact | 10451-3 |
0070257 | Proinsulin, Intact/Insulin Ratio Calc | 45338-1 |