Ordering Recommendation

Preferred initial screening test for prostate cancer in conjunction with digital rectal exam. Use to monitor patients for recurrence of cancer.


Quantitative Electrochemiluminescent Immunoassay




Within 24 hours

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Serum Separator Tube (SST). Also acceptable: Green (lithium heparin), Lavender (K2EDTA), or Pink (K2EDTA).

Specimen Preparation

Transport 1 mL serum or plasma in an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Hemolyzed specimens.


Ambient: 24 hours; Refrigerated: 5 days; Frozen: 6 months

Reference Interval

0.0-4.0 ng/mL

Interpretive Data

The Roche PSA electrochemiluminescent immunoassay is used. Results obtained with different test methods or kits cannot be used interchangeably. The Roche PSA method is approved for use as an aid in the detection of prostate cancer when used in conjunction with a digital rectal exam in individuals with a prostate age 50 years and older. The Roche PSA is also indicated for the serial measurement of PSA to aid in the prognosis and management of prostate cancer patients. Elevated PSA concentrations can only suggest the presence of prostate cancer until biopsy is performed. PSA concentrations can also be elevated in benign prostatic hyperplasia or inflammatory conditions of the prostate. PSA is generally not elevated in healthy individuals or individuals with nonprostatic carcinoma. 

Compliance Category



This test should be ordered for screening purposes for Medicare patients only.

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0070234 Prostate Spec Ag Total Screen 83112-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • PSA
  • Screen for Prostate Specific Ag
  • sPSA
Prostate Specific Antigen, Total - Medicare Screening