Ordering Recommendation

Preferred initial screening test for prostate cancer in conjunction with digital rectal exam. Use to monitor patients for recurrence of cancer.

Mnemonic
PSA
Methodology

Quantitative Electrochemiluminescent Immunoassay

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum Separator Tube (SST) or Plasma Separator Tube (PST). Also acceptable: Plain Red, Green (Sodium or Lithium Heparin), Lavender (EDTA), or Pink (K2EDTA).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Grossly hemolyzed specimens. Vaginal washings.

Remarks
Stability

After separation from cells: Ambient: 24 hours; Refrigerated: 3 days; Frozen: 6 months

Reference Interval

0.0-4.0 ng/mL

Interpretive Data

The Roche PSA electrochemiluminescent immunoassay is used. Results obtained with different test methods or kits cannot be used interchangeably. The Roche PSA method is approved for use as an aid in the detection of prostate cancer when used in conjunction with a digital rectal exam in men age 50 and older. The Roche PSA is also indicated for the serial measurement of PSA to aid in the prognosis and management of prostate cancer patients. Elevated PSA concentrations can only suggest the presence of prostate cancer until biopsy is performed. PSA concentrations can also be elevated in benign prostatic hyperplasia or inflammatory conditions of the prostate. PSA is generally not elevated in healthy men or men with non-prostatic carcinoma.

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

84153

Components
Component Test Code* Component Chart Name LOINC
0070121 Prostate Specific Antigen, Total 83112-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • PSA
  • SPSA
  • Total PSA
Prostate Specific Antigen, Total