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Testosterone, Bioavailable and Sex Hormone Binding Globulin (Includes Total Testosterone), Adult Male
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Ordering Recommendation
Acceptable test for the evaluation of suspected hypogonadism in men. Not recommended for use in women and children.
Mnemonic
Methodology
Quantitative Electrochemiluminescent Immunoassay
The concentrations of free and bioavailable testosterone are derived from mathematical expressions based on constants for the binding of testosterone to albumin and/or sex hormone binding globulin.
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
Specimen Required
Collect specimen between 6-10 a.m.
Serum separator tube or green (lithium heparin).
Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.6 mL)
Refrigerated.
EDTA plasma.
After separation from cells: Ambient: 48 hours; Refrigerated: 1 week; Frozen: 2 months
Reference Interval
| Test Number |
Components |
Reference Interval |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0070111 | Testosterone Free, Adult Male | Male: 14-15 years: 3-138 pg/mL 16-17 years: 38-173 pg/mL 18 years and older: 47-244 pg/mL Tanner Stage IV: 35-169 pg/mL Tanner Stage V: 41-239 pg/mL |
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| 0070130 | Testosterone, Adult Male | Male: 14-15 years: 33-585 ng/dL 16-17 years: 185-886 ng/dL 18-39 years: 300-1080 ng/dL 40-59 years: 300-890 ng/dL 60 years and older: 300-720 ng/dL Tanner Stage IV: 165-854 ng/dL Tanner Stage V: 194-783 ng/dL |
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| 0099375 | Sex Hormone Binding Globulin |
|
| Component |
Reference Interval |
|---|---|
| Testosterone, Bioavailable, Adult Male | 14-15 years: 10-337 ng/dL 16-17 years: 35-509 ng/dL 18 years and older: 131-682 ng/dL Tanner Stage IV: 40-485 ng/dL Tanner Stage V: 124-596 ng/dL |
| Testosterone, Percentage Free, Adult Male | 1.6-2.9% |
Interpretive Data
Bioavailable testosterone concentration is calculated using total testosterone (measured by immunoassay) and the binding constant of testosterone and sex hormone binding globulin (SHBG) and/or albumin. Testosterone immunoassys are both imprecise and inaccurate at low testosterone concentrations, usch as those found in children and cisgender females. For these individuals testing by mass spectrometry is reccomended; refer to Testosteron, Bioavaialble and Total, includes Sex-Hormone Binding Globulin (Adult Females, Children or Individual on Testosterone Supressing Hormone Therapy) (ARUP test code 0081057).
For individuals of testosterone hormone therapy refer to cisgender male reference intervals. No reference intervals have been establised for males youger then 14 years or for cisgender females. For a complete set of all established reference interals, refer to ltd.aruplab.com/Tests/Pub/0070102.
The concentration of Free Testosterone is derived from a mathematical expression based on the constant for the binding of testosterone to Sex Hormone Binding Globulin (SHBG).
FDA
Note
Plese refer to individual components for stability fot this test. This test is not reccommended for females or children. For testsing on females or children refer to Testoterone, Bioavailable and Toal, includes Sex Hormone Binding Globuln (adult Females, Children, or Individulas on Tetosterone Supressing Hormone Therapy) Testosterone, Bioavaliable & Sex Hormone Binding Globulin (includes Total Testosterone), Females or Children (0081057).
Hotline History
CPT Codes
84402; 84403; 84270
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0070113 | Testosterone, Free Calculation | 2991-8 |
| 0070114 | Testosterone, Percentage Free | 15432-8 |
| 0070130 | Testosterone, Adult Male | 2986-8 |
| 0070134 | Testosterone, Bioavailable | 2990-0 |
| 0099375 | Sex Hormone Binding Globulin | 13967-5 |
Aliases
- TeBG
- Testosterone-estrogen Binding Globulin
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