Growth Hormone, Timed - Other

0070069
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Standard

Ordering Recommendation

Mnemonic

GH OTHER

Methodology

Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Plasma separator tube or serum separator tube. Also acceptable: Green (sodium or lithium heparin) or lavender (EDTA).

Specimen Preparation

Transport 1 mL serum or plasma. (Min: 0.4 mL)

Storage/Transport Temperature

Frozen. Also acceptable: Refrigerated.

Unacceptable Conditions

Tissue or urine. Grossly hemolyzed or lipemic specimens.

Remarks
Stability

Ambient: 24 hours; Refrigerated: 1 week; Frozen: 2 months

Reference Interval

Interpretive Data

For pediatric patients, very low peak growth hormone (GH) concentrations on stimulation testing are consistent with severe GH deficiency (GHD). Thresholds distinguishing normal from partial GHD have not been well established. Inadequate response to two different provocative tests is required for diagnosis of GHD. (Grimberg et al. Horm Res Paediatr 2016;86:361-397).
 
In adults, expected peak GH concentrations depend on the stimulation test performed, as described in Endocrine Society guidelines for the evaluation and treatment of adults with GHD (Yuen KCJ et al. Endocr Pract. 2019;25(11):1191-1232).
 
For suppression testing, healthy subjects have GH concentrations of less than 1 ng/mL within 2 hours of ingestion of a 75 or 100 gram glucose dose. Patients with acromegaly fail to show normal suppression. (Katznelson et al. J Clin Endocrinol Metab, 2014, 99(11):3933-3951).

Compliance Category

FDA

Note

This Growth Hormone assay is now standardized to the Recombinant Second International Standard (IS): 98/574. Growth hormone results read approximately 25 percent lower than with the previous standards (First IS: 80/505). Reference ranges have also been modified according to the assay manufacturer.

Hotline History

N/A

CPT Codes

83003

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Components

Component Test Code* Component Chart Name LOINC
0020573 Growth Hormone, Time (Minutes) 50220-3
0070069 Growth Hormone, Other 2963-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • GH
  • GH testing
  • GHRH
  • Growth Hormone Provocative Test
  • Growth Hormone Stimulation
  • growth hormone, Serum
  • hGH
  • Human Growth Hormone
  • Somatotrophic Hormone
  • Somatotropin
Growth Hormone, Timed - Other