Ordering Recommendation

Aid in evaluation of patient with allergic signs and symptoms, such as anaphylaxis. May assist when diagnosing and monitoring mast-cell activation disorders or when evaluating histamine production over a longer time frame.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Random or 24-hour urine in a plastic container. Refrigerate during collection.

Specimen Preparation

Transfer a 4 mL aliquot from a well-mixed random or 24-hour collection to an ARUP Standard Transport Tube and freeze immediately. (Min: 1 mL) Record total volume and collection time interval on transport tube and test request form.

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Ambient: Unacceptable; Refrigerated: 6 hours; Frozen: 6 months


Quantitative Enzyme Immunoassay


Tue, Sat


1-6 days

Reference Interval

Effective February 21, 2012

Components Reference Interval
Histamine, Urine - ratio to CRT 0-450 nmol/g crt
Histamine, Urine, Excretion - 24h 0-60 µg/day

Interpretive Data

Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


If 24-hour urine is submitted, the excretion will be calculated. If random urine is submitted, the result will be reported as "Not applicable."

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0020207 Creatinine, Urine - per volume 2161-8
0070039 Histamine, Urine - per volume 33290-8
0070041 Histamine, Urine - ratio to CRT 25925-9
0097110 Total Volume 19153-6
0097111 Hours Collected 30211-7
2005776 Histamine, Urine, Excretion - 24 h 9410-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • urine histamine
Histamine, Urine