Ordering Recommendation

Aid in evaluation of patient with allergic signs and symptoms, such as anaphylaxis. May assist when diagnosing and monitoring mast-cell activation disorders or when evaluating histamine production over a longer time frame.


Quantitative Enzyme Immunoassay


Tue, Sat


1-6 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Random or 24-hour urine in a plastic container. Refrigerate during collection.

Specimen Preparation

Transfer a 4 mL aliquot from a well-mixed random or 24-hour collection to an ARUP Standard Transport Tube and freeze immediately. (Min: 1 mL) Record total volume and collection time interval on transport tube and test request form.

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Ambient: Unacceptable; Refrigerated: 6 hours; Frozen: 6 months

Reference Interval

Effective February 21, 2012

Components Reference Interval
Histamine, Urine - ratio to CRT 0-450 nmol/g crt
Histamine, Urine, Excretion - 24h 0-60 µg/day

Interpretive Data

Compliance Category

Laboratory Developed Test (LDT)


If 24-hour urine is submitted, the excretion will be calculated. If random urine is submitted, the result will be reported as Not applicable.

Hotline History
CPT Codes


Component Test Code* Component Chart Name LOINC
0020207 Creatinine, Urine - per volume 2161-8
0070039 Histamine, Urine - per volume 33290-8
0070041 Histamine, Urine - ratio to CRT 25925-9
0097110 Total Volume 19153-6
0097111 Hours Collected 30211-7
2005776 Histamine, Urine, Excretion - 24 h 9410-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • urine histamine
Histamine, Urine