Ordering Recommendation
Screen, diagnose, and monitor diseases associated with excess or deficient cortisol production.
Mnemonic
Methodology
Quantitative Electrochemiluminescent Immunoassay
Performed
Sun-Sat
Reported
Within 24 hours
New York DOH Approval Status
Specimen Required
Collect 1 timed specimen at 0 minutes.
Serum separator tube (SST) or Plain Red, Green (lithium heparin), Lavender (K2 EDTA and K3 EDTA), or Pink (K2 EDTA)
Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL) Specimen must be labeled with time drawn.
Refrigerated.
After separation from cells: Ambient: 24 hours; Refrigerated:4 days; Frozen: 12 months (avoid repeated freeze/thaw cycles)
Reference Interval
By report
Interpretive Data
6 a.m. - 10 a.m. reference interval: 6.0-18.4 µg/dL
4 p.m. - 8 p.m. reference interval: 2.7-10.5 µg/dL
8 hrs post 1 mg dexamethasone given at midnight: 0.0 - 5.0 µg/dL
Normal peak serum cortisol is greater than 18.0 µg/dL at 30 or 60 minutes after 250 micrograms of cosyntropin I.V.
FDA
Note
To convert to nmol/L, multiply µg/dL by 27.6.
Hotline History
Hotline History
CPT Codes
82533
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0070031 | Cortisol 0 Min | 41407-8 |
Aliases
- Adrenal Corticotropin Hormone
- Corticotropin
- Cortisol
- Cortrosyn
- Cosyntropin