Ordering Recommendation

Differential diagnosis of Cushing syndrome. Screen and diagnose primary and secondary adrenal insufficiency.

Mnemonic
CORTISOL
Methodology

Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube (SST).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube.(Min: 0.6 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Saliva (refer to Cortisol, Saliva, ARUP test code 0081117).

Remarks
Stability

After separation from cells: Ambient: 1 week; Refrigerated: 1 week; Frozen: 3 months

Reference Interval
Interpretive Data

0800 hours: 6.0-23.0 µg/dL
2000 hours: 0.0-9.0 µg/dL
8 hours post 1 mg dexamethasone given at midnight: 0.0-5.0 µg/dL
30-60 minutes post 25 units Cosyntropin I.V.: > 20.0 µg/dL

No compliance statements are in use for this test.

Note

To convert to nmol/L, multiply µg/dL by 27.6.

Hotline History
N/A
CPT Codes

82533

Components
Component Test Code* Component Chart Name LOINC
0070030 Cortisol, Serum 2143-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Compound F
  • Corticosteroids
  • Cortisol
  • Cortisol, Serum
  • Cortrosyn Stimulation Test
  • Dexamethasone Suppression
  • Diurnal Corticoids
Cortisol, Serum