Antibiotic Level, Piperacillin

0060842
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Example Reports
Standard

Ordering Recommendation

Monitor levels of antimicrobial drug, piperacillin.

Mnemonic

ML PIP

Methodology

Quantitative Bioassay

Performed

Sun-Sat

Reported

2-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Plain red.

Specimen Preparation

Aseptically remove 2 mL serum to a sterile tube (ARUP supply #43115) and freeze. Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Plasma.

Remarks

Required information includes: time and date of collection, time of last dose, and list of all antibiotics that the patient is receiving or has received in the past 48 hours.

Stability

Ambient: 2 hours; Refrigerated: 24 hours; Frozen: 1 week

Reference Interval

Interpretive Data

Normal peak serum concentration for piperacillin is 389-484 µg/mL with a 4 g IV dose of piperacillin, 209 µg/mL with a 3.375 g IV dose of piperacillin/tazobactam, or 224 µg/mL with a 4.5 g IV dose of piperacillin/tazobactam. Trough serum concentration is not well established.

For bioassay measurements, the presence of other antimicrobial agents may interfere with the assay. Other factors that may influence antimicrobial levels include inherent differences among patients and their underlying physical conditions as well as the dose and route of administration of the antimicrobial agent.

Compliance Category

Standard

Note

Please include time of last dose, and list of all antibiotics that the patient is receiving or has received in the past 48 hours. This information is important for laboratory handling and essential for subsequent physician interpretation of results.   

Hotline History

N/A

CPT Codes

80299

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Components

Component Test Code* Component Chart Name LOINC
0060853 Antibiotic Level, Piperacillin 3972-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • piperacillin-tazobactam
  • Pipercillin serum level
  • Zosyn
Antibiotic Level, Piperacillin