Ordering Recommendation

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Actively growing isolate of Mycobacterium tuberculosis in pure culture.

Specimen Preparation

Transport sealed container with pure culture on solid or liquid media. Place each specimen in an individually sealed bag.

Storage/Transport Temperature

Room temperature.
Submit specimen according to Infectious Substance, Category A, shipping guidelines.

Unacceptable Conditions

Mixed cultures or non-viable organisms. Organisms submitted on agar plate.


Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: Unacceptable


Broth Macrodilution




21-28 days

Reference Interval

By report

Interpretive Data

The interpretation provided is based on results for the following drugs at the stated concentrations:
Drugs tested: Ethambutol: 5.0 µg/mL, isoniazid: 0.1 µg/mL (0.4 µg/mL if resistant to 0.1 µg/mL), pyrazinamide: 100 µg/mL, and rifampin: 1.0 µg/mL.

This procedure screens isolates of M. tuberculosis complex for drug resistance. The procedure does not use serial dilutions to provide quantitative MIC values. Single critical concentrations for each antimycobacterial agent used have been defined by the United States Public Health Service.

Compliance Category



M. tuberculosis complex isolates mono-resistant to Pyrazinamide (PZA) will be further identified to species by PCR. Additional charges apply.

Hotline History


CPT Codes

87188 x4. CPT codes vary based on method.


Component Test Code* Component Chart Name LOINC
0060347 Susceptibility, M. tuberculosis Primary 29576-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • AFB primary panel
  • Ethambutol susceptibility
  • isoniazid susceptibility
  • pyrazinamide susceptibility
  • rifampin susceptibility
Antimicrobial Susceptibility, AFB/Mycobacterium tuberculosis Primary Panel