Ordering RecommendationRecommendations when to order or not order the test. May include related or preferred tests.
Detect varicella-zoster virus (VZV). Negative or inadequate DFA results are confirmed with culture. DFA sensitivity is highest when performed on scrapings from base of lesions; culture sensitivity is highest when specimens are collected soon after onset of symptoms. Molecular testing is generally preferred; refer to Varicella-Zoster Virus by PCR (0060042).
MnemonicUnique test identifier.
VZVFAC
MethodologyProcess(es) used to perform the test.
Direct Fluorescent Antibody Stain/Cell Culture
PerformedDays of the week the test is performed.
Sun-Sat
ReportedExpected turnaround time for a result, beginning when ARUP has received the specimen.
3-5 days DFA: Within 24 hours; Culture: 3-5 days
New York DOH Approval StatusIndicates test has been approved by the New York State Department of Health.
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect vesicle specimen during first three days of rash.
Collect
Vesicle fluid or swab, tissue, or skin scrapings. Swab should be rolled in base of fresh vesicle to obtain cells.
Specimen Preparation
Immediately transfer specimen to viral transport media (ARUP Supply #12884) and refrigerate (extremely temperature sensitive). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Bone marrow CSF, or whole blood. Calcium alginate, eSwab, dry or wood swabs.
Reference IntervalNormal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Negative
Interpretive DataBackground information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.
Approximately 20% of samples submitted for VZV are positive for herpes simplex virus. Testing for herpes simplex virus is NOT included in this test.
Compliance Category
FDA
NoteAdditional information related to the test.
If DFA is negative or inadequate, then a VZV culture will be added. Additional charges apply.
Sensitivity of DFA methodology is dependent upon adequacy of the specimen. If specimen contains fewer than 20 cells, then the DFA result will be reported as "inadequate."
Hotline History
N/A
CPT CodesThe American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
AliasesOther names that describe the test. Synonyms.
Herpes Zoster
Herpes Zoster Antigen Detection & Culture
Varicella Zoster Virus
Varicella Zoster Virus Antigen Detection
VZV
VZV DFA
Varicella-Zoster Virus DFA with Reflex to Varicella-Zoster Virus Culture