PCR testing is preferred for diagnosis of acute infection. Detect neutralizing antibodies to coxsackie B virus.
Semi-Quantitative Serum Neutralization
Serum Separator Tube (SST) or Plain Red.
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens.
CSF or plasma. Contaminated, hemolyzed, or severely lipemic specimens.
Mark specimens plainly as "acute" or "convalescent."
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Coxsackie B1: Less than 1:10
Coxsackie B2: Less than 1:10
Coxsackie B3: Less than 1:10
Coxsackie B4: Less than 1:10
Coxsackie B5: Less than 1:10
Coxsackie B6: Less than 1:10
Single positive antibody titers of greater than or equal to 1:80 may indicate past or current infection. Seroconversion or an increase in titers between acute and convalescent sera of at least fourfold is considered strong evidence of current or recent infection.
|Component Test Code*||Component Chart Name||LOINC|
|0065111||Coxsackie B Virus Antibody Type 1||5103-7|
|0065112||Coxsackie B Virus Antibody Type 2||5105-2|
|0065113||Coxsackie B Virus Antibody Type 3||5107-8|
|0065123||Coxsackie B Virus Antibody Type 5||5111-0|
|0065124||Coxsackie B Virus Antibody Type 6||5113-6|
|0065130||Coxsackie B Virus Antibody Type 4||5109-4|
- Coxsackie Antibody, Neutralization
- Coxsackie B
- Coxsackie B Antibody Panel-Serum
- Coxsackie B virus antibody profile, IgG, IgM